no long term data
#retatrutide 2025-11-06
Thursday50 messages9 participantstimes are UTC
Highlights from this day
- month_six_me — does the energy expenditure claim show up as anything you can feel 14:35
- glasgow_vial — why does everyone insist on smaller steps here than on the other two 16:01
- glasgow_vial — Medutest came back 96.8 on one lot and 98.1 on the next from the same HJ, both fine 16:17
- HPLC_Hank — coming back to this phase 2 was still trending at the end which is why the phase 3 readout matters more than usual 19:32
research use only
i said 2 months ago that my heart rate had settled and it has stayed settled since
came off at 21 weeks because my resting rate stayed elevated and i didnt like it
blood pressure stayed flat for me while heart rate moved, which i didnt expect
lost 41kg over 17 months at doses well under what the trials used, still working it out
*PeptideMeter not the other one
back after 3 months, has anything actually been published since
does the energy expenditure claim show up as anything you can feel
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coming back to this i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
Batch lookup H-2814: 3 independent reports on file, earliest 2025-05-23.
is TRIUMPH the phase 3 programme
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phase 2 only
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anyone logging resting heart rate on this
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
lost 14kg over 18 months at doses well under what the trials used
stepping in 7.5 increments instead of doubling is the only thing i would change if i started again
i log resting heart rate every morning because of this and its the one number i actually watch
for the archive appetite suppression at 1.7 was stronger than my tirzepatide experience at a comparable point
whats the half life like, is it weekly the same way
reconstituted the 5 vial to 4mg/ml specifically so i could take 1 without measuring crumbs
did anyone come off because of the heart rate
why does everyone insist on smaller steps here than on the other two
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nobody should read my log as a plan, im recording what i did and thats all it is
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Medutest came back 96.8 on one lot and 98.1 on the next from the same HJ, both fine
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sorry to jump in the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
blood pressure stayed flat for me while heart rate moved, which i didnt expect
[edited]did the phase 2 plateau or was it still moving at the end
whats a sensible starting point, im seeing everything from 0.5 to 2
did the phase 2 result actually come in higher than the tirzepatide numbers
smaller steps here
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is the GI worse than tirzepatide or about the same
my resting rate went up 7 bpm in the first month and came back most of the way by month 21
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for the archive buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
right so triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
my resting heart rate is up about 6 bpm, did that settle for anyone
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial, not advice obviously
settled by month three
people insist on small steps because the side effects arrive faster than on the other two
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists, someone check my working
sorry to jump in the heart rate thing is real enough that i mention it whenever someone asks about starting
glucagon is the new bit
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
TRIUMPH is phase 3
update on the earlier thing the half life supports weekly dosing and thats what ive done from the start
coming back to this phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
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anyone stayed at 10 for months rather than climbing
how do people square the research use only framing with logging their own use
the honest position is this has less human evidence behind it than anything else discussed here
stopped for 10 months and restarted at half my old dose, the ramp was easier second time