vialroom

#retatrutide 2026-04-23

Thursday43 messages8 participantstimes are UTC
Highlights from this day
  • pbs_pip — unrelated but back after 25 months, has anything actually been published since 21:24
  • mg_per_ml — GI was about the same as tirzepatide for me, the difference was how fast it arrived, n of 1 obviously 21:29
  • tallinn_taper — the honest position is this has less human evidence behind it than anything else discussed here 21:47
  • wrong_network — stepping in 15 increments instead of doubling is the only thing i would change if i started again 23:10
BN

blood pressure stayed flat for me while heart rate moved, which i didnt expect

MP

how do people square the research use only framing with logging their own use

NS

genuine question my resting heart rate is up about 3 bpm, did that settle for anyone

my resting rate went up 9 bpm in the first month and came back most of the way by month 10

anyone gone above 10 and what changed

🧊4

i log resting heart rate every morning because of this and its the one number i actually watch, happy to be corrected

whats a sensible starting point, im seeing everything from 0.5 to 2

logging rhr daily

MP

stopped for 17 months and restarted at half my old dose, the ramp was easier second time

PP

how slow is low and slow here, four weeks a step or longer

MP

reconstituted the 2 vial to 2mg/ml specifically so i could take 0.25 without measuring crumbs

PP

appetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point

glucagon is the new bit

[edited]

i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind

unrelated but back after 25 months, has anything actually been published since

7

phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan

GI was about the same as tirzepatide for me, the difference was how fast it arrived, n of 1 obviously

baseline  58
wk 2      61
wk 4      64
wk 6      67
wk 8      66
wk 10     65   (held dose from wk 7)

triple agonist yeah

MP

people insist on small steps because the side effects arrive faster than on the other two, for what its worth

mine went up too

did the phase 2 result actually come in higher than the tirzepatide numbers
my resting rate went up 6 bpm in the first month and came back most of the way by month 26

TT

held at 1.7 for 4 months and it never plateaued for me, which i cant explain

research use only

nobody should read my log as a plan, im recording what i did and thats all it is

🎉1

coming back to this the purity spread across lots worries me more than the molecule does

i said 3 months ago that my heart rate had settled and it has stayed settled since

NS

slightly off topic but came off at 5 weeks because my resting rate stayed elevated and i didnt like it

NS

i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps

TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule, we shall see

TT

sorry to jump in the half life supports weekly dosing and thats what ive done from the start

VB

Reminder for non_scale_win: dose day is today. Set 8 days ago.

WN

buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely

update on the earlier thing energy expenditure isnt something i could feel, though my sleep tracker disagreed with me

🙏4

*PeptideMeter not the other one

there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists

stepping in 15 increments instead of doubling is the only thing i would change if i started again

baseline  58
wk 2      61
wk 4      64
wk 6      67
wk 8      66
wk 10     65   (held dose from wk 7)