#retatrutide 2025-08-28

Thursday11 messages4 participantstimes are UTC

Highlights from this day

evidence_or_not — the honest position is this has less human evidence behind it than anything else discussed here, still working it out 09:45
evidence_or_not — i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind 10:20
amylin_amy — there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists, happy to be corrected 10:38
evidence_or_not — i log resting heart rate every morning because of this and its the one number i actually watch 10:39

the honest position is this has less human evidence behind it than anything else discussed here, still working it out

i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind

energy expenditure isnt something i could feel, though my sleep tracker disagreed with me

did the phase 2 plateau or was it still moving at the end

there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists, happy to be corrected

i log resting heart rate every morning because of this and its the one number i actually watch

baseline  58
wk 2      61
wk 4      64
wk 6      67
wk 8      66
wk 10     65   (held dose from wk 7)

research use only is on every vial and i treat it as exactly that, nobody here is prescribing

ok so the heart rate thing is real enough that i mention it whenever someone asks about starting

cant feel it honestly

low and slow

im at 2.5 and the appetite effect is stronger than i expected, normal