phase 2 only
#retatrutide 2026-01-16
Friday49 messages14 participantstimes are UTC
Highlights from this day
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely, i think
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
follow up the half life supports weekly dosing and thats what ive done from the start
follow up phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
lost 40kg over 7 months at doses well under what the trials used
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anyone reconstituting 30 vials to 4 so the steps come out smaller
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual, not advice obviously
i said 3 months ago that my heart rate had settled and it has stayed settled since
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
ok so triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
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whats a sensible starting point, im seeing everything from 0.5 to 2
i log resting heart rate every morning because of this and its the one number i actually watch
nobody should read my log as a plan, im recording what i did and thats all it is
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
stepping in 1.7 increments instead of doubling is the only thing i would change if i started again
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
is the glucagon arm what people mean by the energy expenditure thing
came off at 14 weeks because my resting rate stayed elevated and i didnt like it
does the energy expenditure claim show up as anything you can feel
back after 21 months, has anything actually been published since
genuine question and im not trying to start anything. why does this channel exist if the compound isnt approved
fair question and its been asked properly about twice a year since 2023
the archive exists because people are going to do this whether or not there is somewhere to write it down
somewhere to write it down means the heart rate logs exist, the bad lots get named, and the person at 71 bpm sees that someone else held their dose
thats the whole argument and it hasnt changed
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but you dont tell people to take it
never. nobody in here has the standing to and the ones who try get told
and i will keep saying the boring part. no approval means no long term safety dataset. not a reassuring absence, an actual absence
the phase 2 was 48 weeks. thats not long term by any definition
correct. we know nothing published about year three
what would change your mind about how careful to be
the outcomes trial in the TRIUMPH programme reporting, honestly. thats the one i am waiting on
and until then the community line has been low and slow, log everything, and dont chase the 24%
which about half the channel ignores
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about half. the other half write it down, which is why the logs are useful
we nearly did not open this channel. the deciding argument was that people were already discussing it in #other-peptides with no test data attached
at least here the discussion drags a COA along behind it
that makes sense. thanks for answering seriously
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you asked seriously
also read #scam-watch before you buy anything labelled reta. the fake rate on this one has been the worst of any compound we track
there have been vials that assayed as tirzepatide, vials that assayed as nothing much, and one memorable lot that was a GLP-1 that nobody could identify
how do you even find that out
you pay for mass spec. Janoshik will tell you what is actually in there, not just how pure the thing you hoped for was
identity first, purity second, content third. in that order, always
pin that
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already pinned in #coa-reading, but ill mirror it
the absence of data point you made — is that specific to reta or true of the others too
much less true of sema. that has years of cardiovascular outcome data now. tirz is catching up. reta has 48 weeks and a promise
understood