the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
#retatrutide 2026-06-01
Monday25 messages7 participantstimes are UTC
Highlights from this day
- fridge_thermo — blood pressure stayed flat for me while heart rate moved, which i didnt expect, thats one data point 21:15
- septum_sal — how slow is low and slow here, four weeks a step or longer 21:22
- customs_owl — the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me people insist on small steps because the side effects arrive faster… 21:35
- customs_owl — follow up is the GI worse than tirzepatide or about the same the half life supports weekly dosing and thats what ive done from the start 22:01
- customs_owl — unrelated but reconstituted the 10 vial to 4mg/ml specifically so i could take 1.7 without measuring crumbs 22:13
watching my heart rate
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blood pressure stayed flat for me while heart rate moved, which i didnt expect, thats one data point
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back after 23 months, has anything actually been published since
im at 15 and the appetite effect is stronger than i expected, normal
how slow is low and slow here, four weeks a step or longer
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glucagon is the new bit
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
people insist on small steps because the side effects arrive faster than on the other two
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there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
mine went up too
follow up is the GI worse than tirzepatide or about the same
the half life supports weekly dosing and thats what ive done from the start
settled by month three
unrelated but reconstituted the 10 vial to 4mg/ml specifically so i could take 1.7 without measuring crumbs
cant feel it honestly
triple agonist yeah
low and slow
i said 6 months ago that my heart rate had settled and it has stayed settled since
research use only
anyone stayed at 15 for months rather than climbing
while im here the heart rate thing is real enough that i mention it whenever someone asks about starting
phase 2 only
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual