smaller steps here
#retatrutide 2025-11-27
Thursday40 messages12 participantstimes are UTC
Highlights from this day
- assay_low_al — stepping in 1.7 increments instead of doubling is the only thing i would change if i started again 19:57
- assay_not_purity — genuine question is the phase 2 dosing anywhere near what people here run 20:53
- assay_not_purity — unrelated but people insist on small steps because the side effects arrive faster than on the other two 21:13
- electrolyte_eli — reconstituted the 30 vial to 8mg/ml specifically so i could take 5 without measuring crumbs, i could be wrong 21:14
- factory_direct_fi — for the archive PeptideMeter came back 97.4 on one lot and 99.4 on the next from the same WWB, both fine 22:28
i log resting heart rate every morning because of this and its the one number i actually watch
glucagon is the new bit
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
whats the half life like, is it weekly the same way
the honest position is this has less human evidence behind it than anything else discussed here
stepping in 1.7 increments instead of doubling is the only thing i would change if i started again
fridge-temps.csv
522 rows · not retained in the public archive
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the half life supports weekly dosing and thats what ive done from the start
quick one the heart rate thing is real enough that i mention it whenever someone asks about starting
phase 2 only
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
unrelated but does the glucagon arm explain the heart rate or is that unrelated
anyone reconstituting 20 vials to 2 so the steps come out smaller
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
while im here buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
held at 1.7 for 11 months and it never plateaued for me, which i cant explain
is TRIUMPH the phase 3 programme
[edited]update on the earlier thing no idea whether the heart rate settles for everyone, mine did and one log isnt data, i have it written down somewhere
is the glucagon arm what people mean by the energy expenditure thing
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
genuine question is the phase 2 dosing anywhere near what people here run
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)is the GI worse than tirzepatide or about the same
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
while im here the purity spread across lots worries me more than the molecule does
unrelated but people insist on small steps because the side effects arrive faster than on the other two
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reconstituted the 30 vial to 8mg/ml specifically so i could take 5 without measuring crumbs, i could be wrong
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slightly off topic but does the energy expenditure claim show up as anything you can feel
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
anyone logging resting heart rate on this
stopped for 16 months and restarted at half my old dose, the ramp was easier second time
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
how do people square the research use only framing with logging their own use
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my resting rate went up 9 bpm in the first month and came back most of the way by month 24
anyone stayed at 7.5 for months rather than climbing
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
for the archive PeptideMeter came back 97.4 on one lot and 99.4 on the next from the same WWB, both fine
triple agonist yeah
watching my heart rate
appetite suppression at 2 was stronger than my tirzepatide experience at a comparable point