did the phase 2 result actually come in higher than the tirzepatide numbers
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#retatrutide 2026-03-08
Sunday38 messages6 participantstimes are UTC
Highlights from this day
- calgary_cold — genuine question triple agonist meaning GLP-1, GIP and glucagon, have i got that right 19:07
- escalation_anxiety — the heart rate thing is real enough that i mention it whenever someone asks about starting 19:31
- two_eight_c — i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind 20:30
low and slow
lost 15kg over 22 months at doses well under what the trials used
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is the phase 2 dosing anywhere near what people here run
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
triple agonist yeah
blood pressure stayed flat for me while heart rate moved, which i didnt expect
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
held at 7.5 for 14 months and it never plateaued for me, which i cant explain
cant feel it honestly
phase 2 only
whats the half life like, is it weekly the same way
TRIUMPH is phase 3
glucagon is the new bit
for the archive research use only is on every vial and i treat it as exactly that, nobody here is prescribing
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why does everyone insist on smaller steps here than on the other two
people insist on small steps because the side effects arrive faster than on the other two
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
watching my heart rate
reconstituted the 2 vial to 2.5mg/ml specifically so i could take 2.5 without measuring crumbs
how long before people saw the first change at 5
*Medutest not the other one
my resting heart rate is up about 8 bpm, did that settle for anyone
genuine question triple agonist meaning GLP-1, GIP and glucagon, have i got that right
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the honest position is this has less human evidence behind it than anything else discussed here
janoshik-f-1330.pdf
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stepping in 0.25 increments instead of doubling is the only thing i would change if i started again
back after 26 months, has anything actually been published since
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logging rhr daily
no long term data
the heart rate thing is real enough that i mention it whenever someone asks about starting
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)stopped for 7 months and restarted at half my old dose, the ramp was easier second time
vial-b-0329-front.png
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there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
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TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
does the glucagon arm explain the heart rate or is that unrelated
i said 5 months ago that my heart rate had settled and it has stayed settled since
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
transit-times.csv
124 rows · not retained in the public archive
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is TRIUMPH the phase 3 programme
research use only