settled by month three
#retatrutide 2026-04-05
Sunday54 messages11 participantstimes are UTC
Highlights from this day
- VialBot — Inter-lab diff for lot A-2418: 98.1% vs 99.4%. Within expected range. 19:04
- no_appetite_nia — GI was about the same as tirzepatide for me, the difference was how fast it arrived 19:59
- bea_reconstitutes — people insist on small steps because the side effects arrive faster than on the other two, ill dig out the number 21:11
- triumph_watch — triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history 21:17
- triumph_watch — how slow is low and slow here, four weeks a step or longer 21:52
phase 2 only
no long term data
did anyone come off because of the heart rate
the heart rate thing is real enough that i mention it whenever someone asks about starting
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
Inter-lab diff for lot A-2418: 98.1% vs 99.4%. Within expected range.
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stepping in 1 increments instead of doubling is the only thing i would change if i started again
my resting heart rate is up about 8 bpm, did that settle for anyone
stopped for 1 months and restarted at half my old dose, the ramp was easier second time
is the GI worse than tirzepatide or about the same
cant feel it honestly
lost 15kg over 13 months at doses well under what the trials used, n of 1 obviously
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
low and slow
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VendorInvestigate came back 98.1 on one lot and 97.4 on the next from the same GL Biochem, both fine
watching my heart rate
anyone tracking blood pressure alongside the heart rate
right so anyone gone above 12 and what changed
came off at 21 weeks because my resting rate stayed elevated and i didnt like it
GI was about the same as tirzepatide for me, the difference was how fast it arrived
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glucagon is the new bit
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind, from memory
coming back to this anyone reconstituting 30 vials to 2.5 so the steps come out smaller
did the phase 2 plateau or was it still moving at the end
anyone logging resting heart rate on this
nobody should read my log as a plan, im recording what i did and thats all it is
right so TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
[edited]*PeptideMeter not the other one
no idea whether the heart rate settles for everyone, mine did and one log isnt data, take that with a pinch of salt
TRIUMPH is phase 3
sat at 15 for 9 months rather than climbing and it kept working, so i never went up
mine went up too
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slightly off topic but whats a sensible starting point, im seeing everything from 0.5 to 2
whats the half life like, is it weekly the same way
people insist on small steps because the side effects arrive faster than on the other two, ill dig out the number
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how do people square the research use only framing with logging their own use
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
the honest position is this has less human evidence behind it than anything else discussed here
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triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
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reconstituted the 30 vial to 10mg/ml specifically so i could take 2 without measuring crumbs, anyway
did the phase 2 result actually come in higher than the tirzepatide numbers
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
while im here does the energy expenditure claim show up as anything you can feel
smaller steps here
appetite suppression at 0.25 was stronger than my tirzepatide experience at a comparable point
how slow is low and slow here, four weeks a step or longer
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)held mine ages
triple agonist yeah
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
smaller steps here
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im at 2 and the appetite effect is stronger than i expected, normal
ok so my resting rate went up 6 bpm in the first month and came back most of the way by month 11, for what its worth
came off at 23 weeks because my resting rate stayed elevated and i didnt like it
i log resting heart rate every morning because of this and its the one number i actually watch