nobody should read my log as a plan, im recording what i did and thats all it is, take that with a pinch of salt
#retatrutide 2026-02-19
Thursday52 messages11 participantstimes are UTC
Highlights from this day
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
settled by month three
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom, thats one data point
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appetite suppression at 15 was stronger than my tirzepatide experience at a comparable point, not advice obviously
sorry to jump in the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
lost 21kg over 23 months at doses well under what the trials used, for what its worth
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GI was about the same as tirzepatide for me, the difference was how fast it arrived
is the glucagon arm what people mean by the energy expenditure thing
stopped for 20 months and restarted at half my old dose, the ramp was easier second time
phase 2 only
the honest position is this has less human evidence behind it than anything else discussed here
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i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
held at 1.7 for 1 months and it never plateaued for me, which i cant explain
i said 9 months ago that my heart rate had settled and it has stayed settled since, someone check my working
anyone compared their PeptideMeter purity across two different SGN lots
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is the phase 2 dosing anywhere near what people here run
the purity spread across lots worries me more than the molecule does, your mileage will differ
people insist on small steps because the side effects arrive faster than on the other two
Verification log updated: ERP — evidence added, status unchanged.
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my resting heart rate is up about 2 bpm, did that settle for anyone
im at 0.5 and the appetite effect is stronger than i expected, normal
held mine ages
does the glucagon arm explain the heart rate or is that unrelated
logging rhr daily
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
low and slow
did anyone come off because of the heart rate
i log resting heart rate every morning because of this and its the one number i actually watch
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the heart rate thing is real enough that i mention it whenever someone asks about starting
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nettle_notesstopped for 20 months and restarted at half my old dose, the ramp was easier second time
follow up my resting rate went up 9 bpm in the first month and came back most of the way by month 4
Janoshik came back 98.6 on one lot and 99 on the next from the same Homopeptide, both fine
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
did the phase 2 result actually come in higher than the tirzepatide numbers
*Janoshik not the other one
came off at 18 weeks because my resting rate stayed elevated and i didnt like it
is TRIUMPH the phase 3 programme
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)mine went up too
anyone gone above 7.5 and what changed
how slow is low and slow here, four weeks a step or longer
research use only
no idea whether the heart rate settles for everyone, mine did and one log isnt data
did the phase 2 plateau or was it still moving at the end
whats the half life like, is it weekly the same way
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research use only is on every vial and i treat it as exactly that, nobody here is prescribing, someone check my working
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why does everyone insist on smaller steps here than on the other two
sat at 1.7 for 7 months rather than climbing and it kept working, so i never went up
smaller steps here
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buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
is the GI worse than tirzepatide or about the same
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan, ask me again in a month