vialroom

#retatrutide 2026-01-29

Thursday36 messages8 participantstimes are UTC
Highlights from this day
  • tenpence — nobody should read my log as a plan, im recording what i did and thats all it is 14:28
  • factory_direct_fi — my resting heart rate is up about 8 bpm, did that settle for anyone 15:27
  • secretagogue_sy — TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule 17:03
  • tenpence — held at 0.5 for 16 months and it never plateaued for me, which i cant explain 17:21
TE

reconstituted the 30 vial to 5mg/ml specifically so i could take 2 without measuring crumbs

NE

coming back to this the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial

BB

phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan

TE

quick one buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely

TE

whats a sensible starting point, im seeing everything from 0.5 to 2

🧪12
NE

slightly off topic but people insist on small steps because the side effects arrive faster than on the other two

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TE

nobody should read my log as a plan, im recording what i did and thats all it is

baseline  58
wk 2      61
wk 4      64
wk 6      67
wk 8      66
wk 10     65   (held dose from wk 7)
LM

slightly off topic but how do people square the research use only framing with logging their own use

LM

does the energy expenditure claim show up as anything you can feel

back after 8 months, has anything actually been published since

TE

the half life supports weekly dosing and thats what ive done from the start

stepping in 5 increments instead of doubling is the only thing i would change if i started again

FD

ok so the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me

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is the phase 2 dosing anywhere near what people here run

phase 2 only

OS

GI was about the same as tirzepatide for me, the difference was how fast it arrived

FD

watching my heart rate

Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.

anyone logging resting heart rate on this
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps

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KF

lost 22kg over 11 months at doses well under what the trials used
the honest position is this has less human evidence behind it than anything else discussed here

TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule

8🧊5

*week 18 not week 9

SS

energy expenditure isnt something i could feel, though my sleep tracker disagreed with me, i could be wrong

follow up i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps

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logging rhr daily