stepping in 0.5 increments instead of doubling is the only thing i would change if i started again
#retatrutide 2025-07-21
Monday44 messages9 participantstimes are UTC
Highlights from this day
- factory_direct_fi — phase 2 was still trending at the end which is why the phase 3 readout matters more than usual 18:09
- identity_shift — whats a sensible starting point, im seeing everything from 0.5 to 2 20:29
- taper_tess — sat at 5 for 5 months rather than climbing and it kept working, so i never went up 21:15
- night_pin — slightly off topic but whats the half life like, is it weekly the same way 21:24
the heart rate thing is real enough that i mention it whenever someone asks about starting
settled by month three
i said 8 months ago that my heart rate had settled and it has stayed settled since
cant feel it honestly
appetite suppression at 1.7 was stronger than my tirzepatide experience at a comparable point
no idea whether the heart rate settles for everyone, mine did and one log isnt data
mine went up too
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)Batch lookup B-0114: 2 independent reports on file, earliest 2024-10-09.
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
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is the glucagon arm what people mean by the energy expenditure thing
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
[edited]lost 36kg over 1 months at doses well under what the trials used
no long term data
smaller steps here
people insist on small steps because the side effects arrive faster than on the other two
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
my resting rate went up 7 bpm in the first month and came back most of the way by month 19
right so research use only is on every vial and i treat it as exactly that, nobody here is prescribing
stopped for 7 months and restarted at half my old dose, the ramp was easier second time
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists, ask me again in a month
the purity spread across lots worries me more than the molecule does
held mine ages
the honest position is this has less human evidence behind it than anything else discussed here, not advice obviously
ok so reconstituted the 40 vial to 5mg/ml specifically so i could take 2.5 without measuring crumbs
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
anyone tracking blood pressure alongside the heart rate
blood pressure stayed flat for me while heart rate moved, which i didnt expect, i have it written down somewhere
glucagon is the new bit
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right so anyone compared their PeptideMeter purity across two different WXT lots
whats a sensible starting point, im seeing everything from 0.5 to 2
lot-log.csv
113 rows · not retained in the public archive
the half life supports weekly dosing and thats what ive done from the start
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
triple agonist yeah
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind, from memory
my resting heart rate is up about 7 bpm, did that settle for anyone
update on the earlier thing did the phase 2 result actually come in higher than the tirzepatide numbers
anyone gone above 1.7 and what changed
sat at 5 for 5 months rather than climbing and it kept working, so i never went up
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slightly off topic but whats the half life like, is it weekly the same way
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watching my heart rate
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how slow is low and slow here, four weeks a step or longer
identity_shifti was wrong to call the heart rate a non issue last year, enough people logged it that…
does the energy expenditure claim show up as anything you can feel
im at 10 and the appetite effect is stronger than i expected, normal
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nobody should read my log as a plan, im recording what i did and thats all it is