#retatrutide 2025-07-03

for the archive does the energy expenditure claim show up as anything you can feel

triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history, i think

smaller steps here

blood pressure stayed flat for me while heart rate moved, which i didnt expect, ill dig out the number

i said 3 months ago that my heart rate had settled and it has stayed settled since

does the glucagon arm explain the heart rate or is that unrelated

quick one did the phase 2 result actually come in higher than the tirzepatide numbers

held at 1 for 23 months and it never plateaued for me, which i cant explain

settled by month three

the honest position is this has less human evidence behind it than anything else discussed here

for the archive anyone tracking blood pressure alongside the heart rate

i log resting heart rate every morning because of this and its the one number i actually watch

the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial

i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps

phase 2 was still trending at the end which is why the phase 3 readout matters more than usual, anyway

my resting heart rate is up about 8 bpm, did that settle for anyone

follow up did the phase 2 plateau or was it still moving at the end

phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan, from memory

cant feel it honestly

the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me, happy to be corrected

there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists

while im here stepping in 2.4 increments instead of doubling is the only thing i would change if i started again

stopped for 20 months and restarted at half my old dose, the ramp was easier second time

nobody should read my log as a plan, im recording what i did and thats all it is

TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule

update on the earlier thing the heart rate thing is real enough that i mention it whenever someone asks about starting

why does everyone insist on smaller steps here than on the other two

TRIUMPH is phase 3

On this day 7 years ago this channel logged 103 messages.

glucagon is the new bit, thats one data point

research use only

mine went up too