right so whats the half life like, is it weekly the same way
#retatrutide 2026-02-12
Thursday25 messages6 participantstimes are UTC
Highlights from this day
- sage_sources — back after 15 months, has anything actually been published since 21:05
- HPLC_Hank — held at 12 for 24 months and it never plateaued for me, which i cant explain 21:36
- two_ml_two — phase 2 was still trending at the end which is why the phase 3 readout matters more than usual, ill dig out the number 21:39
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
triple agonist yeah
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
slightly off topic but anyone tracking blood pressure alongside the heart rate
low and slow
stopped for 23 months and restarted at half my old dose, the ramp was easier second time, ymmv
appetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point
the heart rate thing is real enough that i mention it whenever someone asks about starting
is the GI worse than tirzepatide or about the same
did anyone come off because of the heart rate
transit-times.csv
186 rows · not retained in the public archive
blood pressure stayed flat for me while heart rate moved, which i didnt expect, happy to be corrected
is there any long term safety data at all or is it phase 2 and hope
settled by month three
did the phase 2 result actually come in higher than the tirzepatide numbers
watching my heart rate
🎉8⚠️4
back after 15 months, has anything actually been published since
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whats a sensible starting point, im seeing everything from 0.5 to 2
no long term data
lost 21kg over 16 months at doses well under what the trials used
held at 12 for 24 months and it never plateaued for me, which i cant explain
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)🎉12👀1
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual, ill dig out the number
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glucagon is the new bit
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom, anyway