glucagon is the new bit
#retatrutide 2026-03-10
Tuesday16 messages4 participantstimes are UTC
Highlights from this day
- secretagogue_sy — for the archive anyone gone above 10 and what changed 14:30
- secretagogue_sy — how slow is low and slow here, four weeks a step or longer 14:52
- secretagogue_sy — while im here stopped for 6 months and restarted at half my old dose, the ramp was easier second time, ask me again in a month no idea whether the heart rate settles… 14:56
- pinch_not_stretch — i said 8 months ago that my heart rate had settled and it has stayed settled since, ill dig out the number low and slow here means smaller steps than i ever used on… 16:30
GI was about the same as tirzepatide for me, the difference was how fast it arrived
for the archive anyone gone above 10 and what changed
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why does everyone insist on smaller steps here than on the other two
ok so the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
how slow is low and slow here, four weeks a step or longer
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reconstituted the 15 vial to 2mg/ml specifically so i could take 2 without measuring crumbs, ill dig out the number
[edited]while im here stopped for 6 months and restarted at half my old dose, the ramp was easier second time, ask me again in a month
no idea whether the heart rate settles for everyone, mine did and one log isnt data
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
blood pressure stayed flat for me while heart rate moved, which i didnt expect
phase 2 only
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mine went up too
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i said 8 months ago that my heart rate had settled and it has stayed settled since, ill dig out the number
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
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smaller steps here
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)low and slow
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial