TRIUMPH is phase 3
#retatrutide 2026-05-10
Sunday50 messages11 participantstimes are UTC
Highlights from this day
- VialBot — New independent result logged — QST, lot KP-0925, purity 98.1% (Janoshik). 21:22
- food_noise_off — the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial 22:12
- swab_dry_first — is there any long term safety data at all or is it phase 2 and hope 22:21
- u100_pat — how do people square the research use only framing with logging their own use 22:33
anyone gone above 1 and what changed
mine went up too
logging rhr daily
did the phase 2 plateau or was it still moving at the end
i said 6 months ago that my heart rate had settled and it has stayed settled since
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
the heart rate thing is real enough that i mention it whenever someone asks about starting, not advice obviously
no idea whether the heart rate settles for everyone, mine did and one log isnt data, take that with a pinch of salt
cant feel it honestly
does the energy expenditure claim show up as anything you can feel
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
held at 2.4 for 10 months and it never plateaued for me, which i cant explain
triple agonist yeah
im at 1 and the appetite effect is stronger than i expected, normal
New independent result logged — QST, lot KP-0925, purity 98.1% (Janoshik).
anyone logging resting heart rate on this
i log resting heart rate every morning because of this and its the one number i actually watch
whats a sensible starting point, im seeing everything from 0.5 to 2
anyone stayed at 1.7 for months rather than climbing
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
phase 2 only
GI was about the same as tirzepatide for me, the difference was how fast it arrived
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely, ill dig out the number
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
sat at 0.5 for 7 months rather than climbing and it kept working, so i never went up
[edited]triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
anyone reconstituting 40 vials to 2.5 so the steps come out smaller
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
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i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind, your mileage will differ
the half life supports weekly dosing and thats what ive done from the start
i log resting heart rate every morning because of this and its the one number i actually watch
is there any long term safety data at all or is it phase 2 and hope
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i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
no long term data
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my resting rate went up 3 bpm in the first month and came back most of the way by month 4
blood pressure stayed flat for me while heart rate moved, which i didnt expect
how do people square the research use only framing with logging their own use
reconstituted the 15 vial to 8mg/ml specifically so i could take 5 without measuring crumbs
watching my heart rate
right so does the glucagon arm explain the heart rate or is that unrelated
*Janoshik not the other one
the purity spread across lots worries me more than the molecule does
settled by month three
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
is TRIUMPH the phase 3 programme
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how slow is low and slow here, four weeks a step or longer
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stopped for 19 months and restarted at half my old dose, the ramp was easier second time
*VendorInvestigate not the other one