triple agonist meaning GLP-1, GIP and glucagon, have i got that right
#retatrutide 2025-07-31
Thursday34 messages7 participantstimes are UTC
Highlights from this day
- area_percent — is the glucagon arm what people mean by the energy expenditure thing 21:39
- sulphur_burp — no idea whether the heart rate settles for everyone, mine did and one log isnt data 22:00
- meal_prep_mick — genuine question there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists, thats one data point 23:19
cant feel it honestly
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
held mine ages
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sat at 2.5 for 7 months rather than climbing and it kept working, so i never went up
logging rhr daily
how do people square the research use only framing with logging their own use
the honest position is this has less human evidence behind it than anything else discussed here
Janoshik came back 96.8 on one lot and 99 on the next from the same MKM, both fine
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
is the glucagon arm what people mean by the energy expenditure thing
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anyone logging resting heart rate on this
i log resting heart rate every morning because of this and its the one number i actually watch
came off at 17 weeks because my resting rate stayed elevated and i didnt like it
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
no idea whether the heart rate settles for everyone, mine did and one log isnt data
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phase 2 only
no long term data
nobody should read my log as a plan, im recording what i did and thats all it is, thats one data point
watching my heart rate
does the energy expenditure claim show up as anything you can feel
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
update on the earlier thing i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
anyone gone above 1 and what changed
coming back to this appetite suppression at 5 was stronger than my tirzepatide experience at a comparable point
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
the heart rate thing is real enough that i mention it whenever someone asks about starting
ok so lost 31kg over 21 months at doses well under what the trials used
research use only
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
genuine question there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists, thats one data point
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why does everyone insist on smaller steps here than on the other two
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low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
is there any long term safety data at all or is it phase 2 and hope
sat at 0.25 for 8 months rather than climbing and it kept working, so i never went up