update on the earlier thing triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
#retatrutide 2026-03-07
Saturday33 messages8 participantstimes are UTC
Highlights from this day
- willow_waits — phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan, not advice obviously 22:51
- factory_direct_fi — energy expenditure isnt something i could feel, though my sleep tracker disagreed with me 23:03
- pharmac_pen — Medutest came back 96.8 on one lot and 99.2 on the next from the same ERP, both fine 23:48
the purity spread across lots worries me more than the molecule does
did anyone come off because of the heart rate
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how long before people saw the first change at 2.4
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan, not advice obviously
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phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
logging rhr daily
blood pressure stayed flat for me while heart rate moved, which i didnt expect
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)anyone compared their VendorInvestigate purity across two different CPC lots
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
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ok so there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
i said 2 months ago that my heart rate had settled and it has stayed settled since
smaller steps here
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)Purity check: no report on file for lot SG-1177. Nothing logged either way.
whats the half life like, is it weekly the same way
quick one is the glucagon arm what people mean by the energy expenditure thing
back after 10 months, has anything actually been published since
update on the earlier thing GI was about the same as tirzepatide for me, the difference was how fast it arrived
my resting rate went up 4 bpm in the first month and came back most of the way by month 20
the half life supports weekly dosing and thats what ive done from the start
mine went up too
no idea whether the heart rate settles for everyone, mine did and one log isnt data
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unrelated but why does everyone insist on smaller steps here than on the other two
anyone tracking blood pressure alongside the heart rate
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
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how do people square the research use only framing with logging their own use
settled by month three
nobody should read my log as a plan, im recording what i did and thats all it is
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held mine ages
came off at 12 weeks because my resting rate stayed elevated and i didnt like it
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sharps_comedyi was wrong to call the heart rate a non issue last year, enough people logged it that…
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
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Medutest came back 96.8 on one lot and 99.2 on the next from the same ERP, both fine
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