vialroom

#retatrutide 2025-11-20

Thursday35 messages6 participantstimes are UTC
Highlights from this day
  • net_peptide — did the phase 2 plateau or was it still moving at the end 19:40
  • amylin_amy — is the GI worse than tirzepatide or about the same 20:58
  • amylin_amy — people insist on small steps because the side effects arrive faster than on the other two, thats one data point 21:02
  • third_shift — i log resting heart rate every morning because of this and its the one number i actually watch 21:39
  • maintenance_mo — im at 10 and the appetite effect is stronger than i expected, normal 21:56
NP

did the phase 2 plateau or was it still moving at the end

🧊13📈6
NP

triple agonist meaning GLP-1, GIP and glucagon, have i got that right

watching my heart rate

baseline  58
wk 2      61
wk 4      64
wk 6      67
wk 8      66
wk 10     65   (held dose from wk 7)
NP

there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists, i have it written down somewhere

AA

the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me

LL

unrelated but research use only is on every vial and i treat it as exactly that, nobody here is prescribing

AA

why does everyone insist on smaller steps here than on the other two

came off at 8 weeks because my resting rate stayed elevated and i didnt like it

is the GI worse than tirzepatide or about the same

📈7

logging rhr daily

appetite suppression at 7.5 was stronger than my tirzepatide experience at a comparable point

people insist on small steps because the side effects arrive faster than on the other two, thats one data point

🎉3🤝2

ok so i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind

LL

genuine question back after 20 months, has anything actually been published since

LL

nobody should read my log as a plan, im recording what i did and thats all it is

low and slow

i log resting heart rate every morning because of this and its the one number i actually watch

🙏7
NP

phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan

energy expenditure isnt something i could feel, though my sleep tracker disagreed with me

i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind, ymmv