is the non peptide thing why orforglipron doesnt need the fasting rules
#oral-glp1 2026-04-17
Friday40 messages8 participantstimes are UTC
Highlights from this day
- peak_split — yes, and thats the unusual bit. the tablet is essentially creating its own little microenvironment 17:08
- batch_bandit — the comparison that makes it obvious 18:30
- escalation_anxiety — the unit typo happens in every single one of these conversations 19:23
- batch_bandit — adherence is a side effect profile of its own 21:47
oral was easier on my gut than injecting at what felt like a similar effect, which surprised me, not advice obviously
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PIONEER or OASIS, which one was the higher dose oral
not a peptide
the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted, n of 1 obviously
update on the earlier thing how strict is the 30 minute wait before food for people here
the non peptide agents dose daily without the water ritual, thats the practical difference
unrelated but does coffee count as plain water, asking for obvious reasons
i keep the tablet by the kettle so i take it before i think about food
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fasted every morning
16:52ari_arrives joined the room
why does a tablet version even work. i thought peptides got destroyed in the stomach
mostly they do. the tablet gets round it with a co formulated absorption enhancer called SNAC
SNAC raises the local pH right next to the tablet and helps the peptide cross the stomach lining before it gets chewed up
so it absorbs in the stomach not the intestine
yes, and thats the unusual bit. the tablet is essentially creating its own little microenvironment
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which is exactly why the rules around it are so fussy. you are protecting that microenvironment
the rules being a small sip of water, nothing else, and then wait
about 120ml of plain water maximum and at least 30 minutes before anything else. food, drink, other tablets
and if you break it
you dilute the thing thats doing the work. absorption drops
bioavailability is around 1% when you do everything right. its not a large margin to give away
one percent?
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roughly, yes. thats why the tablet doses look enormous next to the injection
the comparison that makes it obvious
injected sema, weight management: 2.4 mg PER WEEK
oral sema, diabetes doses: 3 / 7 / 14 mg PER DAY
oral sema, obesity dose studied: 50 mg PER DAY
14mg daily = 98mg a week to do roughly what 1mg a week
does by injection. that gap IS the bioavailability.
wait 50mcg daily for obesity?
*50mg not 50mcg. sorry
the unit typo happens in every single one of these conversations
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genuinely. the pinned unit explainer in #dosing-titration exists because of that exact typo
and the PIONEER programme is where the daily doses came from
oral 14mg held up against injected liraglutide on A1c, which is the result that got the tablet taken seriously
note thats a diabetes trial at a diabetes dose. dont read weight numbers off it
the fasting window is the bit that beat me. i am not a person who can not drink coffee for 30 minutes after waking
surely you just get up 30 minutes earlier
yes and i did that for five weeks and then stopped, which is the honest answer most people give eventually
adherence is a side effect profile of its own
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back to the 120ml rule — does it have to be exactly that or is it a guideline
its from the trial protocol and the label, not physics. more water means more dilution, thats the direction. nobody has mapped the curve for you
and thats about as precise as this channel is going to get, which is fine