SNAC does the work
#oral-glp1 2026-02-10
Tuesday35 messages8 participantstimes are UTC
Highlights from this day
- ferritin_fay — why is the oral dose in mg so much bigger than the injectable one 17:22
- two_three_lifts — my weekly log on oral is noisier than my injectable log ever was, same scales same mornings 17:51
- vialkeeper — the fasting rule cost me my breakfast routine and thats the real reason people quit the oral OASIS ran under the same sort of fasting conditions, thats not the… 18:22
- provincial_pat — took mine with breakfast once by accident and that week was a write off 21:05
roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose, thats one data point
the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted
why is the oral dose in mg so much bigger than the injectable one
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i take mine at 6am, is 30 minutes really enough
i keep the tablet by the kettle so i take it before i think about food
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thirty minutes, no cheating
coffee is not plain water. i tried it for a month and my results got worse
splitting a dose made the absorption problem worse rather than better in my own log
orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ
my weekly log on oral is noisier than my injectable log ever was, same scales same mornings
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SNAC raises the local pH and protects it long enough to cross, thats its whole job
roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose
oral was easier on my gut than injecting at what felt like a similar effect, which surprised me, your mileage will differ
the non peptide agents dose daily without the water ritual, thats the practical difference
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genuine question how strict is the 30 minute wait before food for people here
[edited]*VendorInvestigate not the other one
the fasting rule cost me my breakfast routine and thats the real reason people quit the oral
OASIS ran under the same sort of fasting conditions, thats not the variable between the two
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about one percent
ruined my breakfast
[edited]is the non peptide thing why orforglipron doesnt need the fasting rules
plain water only
did anyone go back to injecting after trying oral
PIONEER or OASIS, which one was the higher dose oral
sorry to jump in lost 15kg over 17 months on oral, slower than my injectable stretch, i stuck with it anyway, ymmv
technique probably
how much water exactly, is it a small sip or half a glass
big mg small dose
Reminder set. I will post here in 5 days.
nobody should copy my morning routine, but the timer is the bit i would keep
took mine with breakfast once by accident and that week was a write off
my oral results were inconsistent week to week and i eventually decided it was me, not the tablet
*week 30 not week 2