#oral-glp1 2025-12-09

Tuesday20 messages7 participantstimes are UTC

Highlights from this day

fibre_first — orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ 19:18
VialBot — Inter-lab diff for lot A-2601: 97.4% vs 98.1%. Within expected range. 19:20
chaser_chris — splitting a dose made the absorption problem worse rather than better in my own log 19:30
orfor_watch — i said 6 months ago that my oral results were random, they got consistent once i fixed the water 19:36

my weekly log on oral is noisier than my injectable log ever was, same scales same mornings

went back to injecting

oral was easier on my gut than injecting at what felt like a similar effect, which surprised me

switched from injectable to oral, lost some of the effect, switched back after 5 months

fasted every morning

ok so i was wrong about the water amount, i was using a sip and it needs a lot more than that

the inconsistency is mostly technique and admitting that took me about a year

set a timer

🔥4

OASIS ran under the same sort of fasting conditions, thats not the variable between the two

not a peptide

SNAC does the work

sorry to jump in anyone dosing oral because of a needle problem rather than preference

thirty minutes, no cheating

orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ

Inter-lab diff for lot A-2601: 97.4% vs 98.1%. Within expected range.

big mg small dose

😂6

PIONEER not OASIS

splitting a dose made the absorption problem worse rather than better in my own log

👀3

i said 6 months ago that my oral results were random, they got consistent once i fixed the water

🧊2🎉17👍2

mine was patchy too