the inconsistency is mostly technique and admitting that took me about a year, we shall see
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#oral-glp1 2025-12-19
Friday46 messages10 participantstimes are UTC
Highlights from this day
- nhs_pathway_nell — the inconsistency is mostly technique and admitting that took me about a year, we shall see 20:14
- thursday_thea — my weekly log on oral is noisier than my injectable log ever was, same scales same mornings 20:18
- power_cut_pia — coffee is not plain water. i tried it for a month and my results got worse the non peptide agents dose daily without the water ritual, thats the practical difference 21:31
my weekly log on oral is noisier than my injectable log ever was, same scales same mornings
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follow up oral was easier on my gut than injecting at what felt like a similar effect, which surprised me
roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose
absorption is the variable, not the molecule. same tablet, different morning, different result
nobody should copy my morning routine, but the timer is the bit i would keep
Testing queue: 2 submissions open, 62 awaiting dispatch.
OASIS ran under the same sort of fasting conditions, thats not the variable between the two
orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ
does taking it with any food at all just waste the dose
changed my mind on the plain water rule after reading how SNAC works, its not a formality, for what its worth
whats the bioavailability actually like, i keep seeing about one percent
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plain water only
anyone switched from injectable to oral and kept the same effect
PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
how much water exactly, is it a small sip or half a glass
did anyone go back to injecting after trying oral
follow up the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted
OASIS ran under the same sort of fasting conditions, thats not the variable between the two
splitting a dose made the absorption problem worse rather than better in my own log
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SNAC does the work
technique probably
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SNAC raises the local pH and protects it long enough to cross, thats its whole job
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i do 6am with water and eat at 7, thats been my routine for 18 months
coffee is not plain water. i tried it for a month and my results got worse
the non peptide agents dose daily without the water ritual, thats the practical difference
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i use it because needles are a genuine problem for me, not because i think its better
is the plain water rule actually load bearing or is it a formality
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i was wrong about the water amount, i was using a sip and it needs a lot more than that
coffee doesnt count
lost 21kg over 25 months on oral, slower than my injectable stretch, i stuck with it anyway, someone check my working
i was wrong about the water amount, i was using a sip and it needs a lot more than that
is the non peptide thing why orforglipron doesnt need the fasting rules
*Medutest not the other one
ruined my breakfast
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took mine with breakfast once by accident and that week was a write off, n of 1 obviously
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the fasting window is the difference between a dose and a very expensive tablet
one percent is the number people quote and the spread around it is the actual story
the non peptide orals are the interesting part of this channel now, not oral semaglutide
sorry to jump in anyone dosing oral because of a needle problem rather than preference
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does coffee count as plain water, asking for obvious reasons
mine was patchy too
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did anyone get consistent results on the oral or is it always patchy
PIONEER not OASIS
the non peptide agents dose daily without the water ritual, thats the practical difference
coffee is not plain water. i tried it for a month and my results got worse
about one percent
is orforglipron a peptide at all
quick one how long before the oral did anything measurable for you
while im here i said 25 months ago that my oral results were random, they got consistent once i fixed the water