the non peptide agents dose daily without the water ritual, thats the practical difference
#oral-glp1 2025-12-12
Friday25 messages4 participantstimes are UTC
Highlights from this day
- food_noise_off — took 10 weeks before i saw anything on oral, roughly twice what the injection took me 16:46
- food_noise_off — PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses, i think 16:59
- food_noise_off — back after 10 months, has anything changed on the oral side 17:01
whats the bioavailability actually like, i keep seeing about one percent
[edited]splitting a dose made the absorption problem worse rather than better in my own log
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the non peptide orals are the interesting part of this channel now, not oral semaglutide
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does the 30 minutes start from swallowing or from the water
did OASIS use the same fasting conditions as the earlier work
plain water only
plain water only, about half a glass, then nothing for 30 minutes. i follow it exactly, ask me again in a month
PIONEER or OASIS, which one was the higher dose oral
fasted every morning
coming back to this the fasting window is the difference between a dose and a very expensive tablet
the fasting rule cost me my breakfast routine and thats the real reason people quit the oral, i have it written down somewhere
OASIS ran under the same sort of fasting conditions, thats not the variable between the two
went back to injecting because the morning routine was too fragile around shift work
roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose
i use it because needles are a genuine problem for me, not because i think its better
ruined my breakfast
about one percent
took 10 weeks before i saw anything on oral, roughly twice what the injection took me
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nobody should copy my morning routine, but the timer is the bit i would keep
the oral mg number is bigger because almost none of it gets in, thats the entire reason
switched from injectable to oral, lost some of the effect, switched back after 20 months, someone check my working
is the absorption variability why the oral doses look so high
PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses, i think
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back after 10 months, has anything changed on the oral side
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