coffee doesnt count
#oral-glp1 2026-05-05
Tuesday28 messages7 participantstimes are UTC
Highlights from this day
- orfor_watch — i said 4 months ago that my oral results were random, they got consistent once i fixed the water, i could be wrong 23:03
- acetate_ash — nobody should copy my morning routine, but the timer is the bit i would keep 23:14
- blind_submit — PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses 23:18
- vat_on_import — is the non peptide thing why orforglipron doesnt need the fasting rules 23:40
big mg small dose
roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose
follow up lost 24kg over 18 months on oral, slower than my injectable stretch, i stuck with it anyway
the non peptide agents dose daily without the water ritual, thats the practical difference
the fasting rule cost me my breakfast routine and thats the real reason people quit the oral
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i said 4 months ago that my oral results were random, they got consistent once i fixed the water, i could be wrong
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took 3 weeks before i saw anything on oral, roughly twice what the injection took me
the inconsistency is mostly technique and admitting that took me about a year, for what its worth
PIONEER or OASIS, which one was the higher dose oral
Inter-lab diff for lot B-0114: 99.4% vs 99.2%. Within expected range.
one percent is the number people quote and the spread around it is the actual story
slightly off topic but anyone dosing oral because of a needle problem rather than preference
nobody should copy my morning routine, but the timer is the bit i would keep
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is the absorption variability why the oral doses look so high
technique probably
PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
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anyone tracking whether their oral results line up week to week
does coffee count as plain water, asking for obvious reasons
changed my mind on the plain water rule after reading how SNAC works, its not a formality
switched from injectable to oral, lost some of the effect, switched back after 3 months
absorption is the variable, not the molecule. same tablet, different morning, different result
[edited]the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted, anyway
plain water only
is the non peptide thing why orforglipron doesnt need the fasting rules
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why is the oral dose in mg so much bigger than the injectable one
tea also does not count, in case anyone was hoping
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SNAC raises the local pH and protects it long enough to cross, thats its whole job