took 24 weeks before i saw anything on oral, roughly twice what the injection took me
#oral-glp1 2025-08-23
Saturday49 messages11 participantstimes are UTC
Highlights from this day
- lot_number_lou — coffee is not plain water. i tried it for a month and my results got worse 20:16
- protein_floor — OASIS ran under the same sort of fasting conditions, thats not the variable between the two 20:52
- mcg_not_mg — went back to injecting because the morning routine was too fragile around shift work 21:24
- aliquot_ada — anyone switched from injectable to oral and kept the same effect 22:08
- mcg_not_mg — is orforglipron a peptide at all 22:48
does SNAC do anything other than get it through the stomach
switched from injectable to oral, lost some of the effect, switched back after 4 months
roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose
the non peptide agents dose daily without the water ritual, thats the practical difference
is the inconsistency people report about the drug or about how they take it
does the 30 minutes start from swallowing or from the water
my oral results were inconsistent week to week and i eventually decided it was me, not the tablet
[edited]PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
is the absorption variability why the oral doses look so high
big mg small dose
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back after 9 months, has anything changed on the oral side
plain water only
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coffee doesnt count
coffee is not plain water. i tried it for a month and my results got worse
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splitting a dose made the absorption problem worse rather than better in my own log
why is the oral dose in mg so much bigger than the injectable one
OASIS ran under the same sort of fasting conditions, thats not the variable between the two
one percent is the number people quote and the spread around it is the actual story
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i keep the tablet by the kettle so i take it before i think about food, ymmv
the fasting window is the difference between a dose and a very expensive tablet, still working it out
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ok so i do 6am with water and eat at 7, thats been my routine for 16 months
the non peptide orals are the interesting part of this channel now, not oral semaglutide
i use it because needles are a genuine problem for me, not because i think its better
slightly off topic but the fasting rule cost me my breakfast routine and thats the real reason people quit the oral
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OASIS ran under the same sort of fasting conditions, thats not the variable between the two
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the oral mg number is bigger because almost none of it gets in, thats the entire reason
about one percent
lot_number_louwhy is the oral dose in mg so much bigger than the injectable one OASIS ran under the…
the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted
how strict is the 30 minute wait before food for people here
mine was patchy too
went back to injecting because the morning routine was too fragile around shift work
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not a peptide
slightly off topic but did anyone get consistent results on the oral or is it always patchy
i take mine at 6am, is 30 minutes really enough
does coffee count as plain water, asking for obvious reasons
did anyone find the oral easier on the gut than the injection
took mine with breakfast once by accident and that week was a write off
i was wrong about the water amount, i was using a sip and it needs a lot more than that
thirty minutes, no cheating
plain water only, about half a glass, then nothing for 30 minutes. i follow it exactly
anyone switched from injectable to oral and kept the same effect
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set a timer
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nobody should copy my morning routine, but the timer is the bit i would keep
PIONEER not OASIS
whats the bioavailability actually like, i keep seeing about one percent
went back to injecting
[edited]why does the same tablet do different things week to week
is orforglipron a peptide at all
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tea also does not count, in case anyone was hoping