the non peptide orals are the interesting part of this channel now, not oral semaglutide
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#oral-glp1 2026-05-01
Friday50 messages10 participantstimes are UTC
Highlights from this day
roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose
plain water only
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the fasting window is the difference between a dose and a very expensive tablet, i have it written down somewhere
sorry to jump in switched from injectable to oral, lost some of the effect, switched back after 13 months
[edited]set a timer
splitting a dose made the absorption problem worse rather than better in my own log
anyone switched from injectable to oral and kept the same effect
ruined my breakfast
about one percent
anyone tracking whether their oral results line up week to week
i was wrong about the water amount, i was using a sip and it needs a lot more than that
thirty minutes, no cheating
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i said 26 months ago that my oral results were random, they got consistent once i fixed the water
the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them
orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ
one percent is the number people quote and the spread around it is the actual story
does taking it with any food at all just waste the dose
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why does the same tablet do different things week to week
mine was patchy too
i keep the tablet by the kettle so i take it before i think about food, still working it out
is there any point splitting an oral dose
Digest for the week of 2025-11-27 has been published.
orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ
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the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted
coffee doesnt count
my oral results were inconsistent week to week and i eventually decided it was me, not the tablet
is the plain water rule actually load bearing or is it a formality
did anyone get consistent results on the oral or is it always patchy
technique probably
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fasted every morning
absorption is the variable, not the molecule. same tablet, different morning, different result
coming back to this tea also does not count, in case anyone was hoping
SNAC does the work
my weekly log on oral is noisier than my injectable log ever was, same scales same mornings
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how strict is the 30 minute wait before food for people here
[edited]why is the oral dose in mg so much bigger than the injectable one
the fasting rule cost me my breakfast routine and thats the real reason people quit the oral
PIONEER or OASIS, which one was the higher dose oral
relabel_watchmy oral results were inconsistent week to week and i eventually decided it was me, not…
back after 17 months, has anything changed on the oral side
not a peptide
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big mg small dose
i do 6am with water and eat at 7, thats been my routine for 13 months
does the 30 minutes start from swallowing or from the water
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took 31 weeks before i saw anything on oral, roughly twice what the injection took me
went back to injecting
whats the bioavailability actually like, i keep seeing about one percent
[edited]SNAC raises the local pH and protects it long enough to cross, thats its whole job
[edited]PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
did anyone go back to injecting after trying oral