SNAC raises the local pH and protects it long enough to cross, thats its whole job
#oral-glp1 2026-03-27
Friday13 messages4 participantstimes are UTC
Highlights from this day
- chlorhex — whats the bioavailability actually like, i keep seeing about one percent 19:57
- bench_notes — anyone dosing oral because of a needle problem rather than preference coffee is not plain water. i tried it for a month and my results got worse 21:01
- slow.taper — coming back to this absorption is the variable, not the molecule. same tablet, different morning, different result 21:02
plain water only
whats the bioavailability actually like, i keep seeing about one percent
🧊2
roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose
anyone tracking whether their oral results line up week to week
big mg small dose
i said 24 months ago that my oral results were random, they got consistent once i fixed the water
why is the oral dose in mg so much bigger than the injectable one
the non peptide orals are the interesting part of this channel now, not oral semaglutide
went back to injecting because the morning routine was too fragile around shift work
mine was patchy too
anyone dosing oral because of a needle problem rather than preference
coffee is not plain water. i tried it for a month and my results got worse
coming back to this absorption is the variable, not the molecule. same tablet, different morning, different result