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#oral-glp1 2025-08-02

Saturday27 messages6 participantstimes are UTC
Highlights from this day
  • fasting_insulin — changed my mind on the plain water rule after reading how SNAC works, its not a formality coffee is not plain water. i tried it for a month and my results got worse 17:10
  • split_dose_sam — the oral mg number is bigger because almost none of it gets in, thats the entire reason, thats one data point 17:19
  • identity_shift — took 9 weeks before i saw anything on oral, roughly twice what the injection took me, your mileage will differ 17:53
  • identity_shift — does coffee count as plain water, asking for obvious reasons 19:37
EM

anyone dosing oral because of a needle problem rather than preference

thirty minutes, no cheating

AD

PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses

PIONEER not OASIS

EM

did OASIS use the same fasting conditions as the earlier work

not a peptide

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FI

slightly off topic but anyone switched from injectable to oral and kept the same effect

changed my mind on the plain water rule after reading how SNAC works, its not a formality
coffee is not plain water. i tried it for a month and my results got worse

IS

splitting a dose made the absorption problem worse rather than better in my own log

my oral results were inconsistent week to week and i eventually decided it was me, not the tablet

SD

the oral mg number is bigger because almost none of it gets in, thats the entire reason, thats one data point

IS

is the inconsistency people report about the drug or about how they take it

plain water only

took 9 weeks before i saw anything on oral, roughly twice what the injection took me, your mileage will differ

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AA

the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted

tea also does not count, in case anyone was hoping

big mg small dose

went back to injecting

[edited]
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IS

does coffee count as plain water, asking for obvious reasons

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did anyone go back to injecting after trying oral

is there any point splitting an oral dose