ruined my breakfast
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#oral-glp1 2026-04-27
Monday42 messages9 participantstimes are UTC
Highlights from this day
- see_a_clinician — roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose 16:13
- two_four_ceiling — the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them 16:40
- wren_weighs_in — why does the same tablet do different things week to week 18:23
- freya_fridge — lost 39kg over 7 months on oral, slower than my injectable stretch, i stuck with it anyway, i have it written down somewhere 18:46
- freya_fridge — is there any point splitting an oral dose PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses 19:34
roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose
oral was easier on my gut than injecting at what felt like a similar effect, which surprised me
plain water only, about half a glass, then nothing for 30 minutes. i follow it exactly
did anyone get consistent results on the oral or is it always patchy
the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them
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how long before the oral did anything measurable for you
PIONEER or OASIS, which one was the higher dose oral
coffee is not plain water. i tried it for a month and my results got worse
SNAC does the work
coffee doesnt count
anyone tracking whether their oral results line up week to week
is the inconsistency people report about the drug or about how they take it
my oral results were inconsistent week to week and i eventually decided it was me, not the tablet
did anyone go back to injecting after trying oral
not a peptide
big mg small dose
went back to injecting because the morning routine was too fragile around shift work
is the absorption variability why the oral doses look so high
set a timer
plain water only
the inconsistency is mostly technique and admitting that took me about a year
mine was patchy too
did OASIS use the same fasting conditions as the earlier work
why does the same tablet do different things week to week
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fasted every morning
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the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted
lost 39kg over 7 months on oral, slower than my injectable stretch, i stuck with it anyway, i have it written down somewhere
i said 21 months ago that my oral results were random, they got consistent once i fixed the water
two_four_ceilingthe oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was…
switched from injectable to oral, lost some of the effect, switched back after 19 months
the oral mg number is bigger because almost none of it gets in, thats the entire reason
the fasting window is the difference between a dose and a very expensive tablet
PIONEER not OASIS
thirty_min_waitmy oral results were inconsistent week to week and i eventually decided it was me, not…
is orforglipron a peptide at all
is there any point splitting an oral dose
PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
about one percent
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OASIS ran under the same sort of fasting conditions, thats not the variable between the two
SNAC raises the local pH and protects it long enough to cross, thats its whole job
thirty minutes, no cheating
technique probably
my weekly log on oral is noisier than my injectable log ever was, same scales same mornings
follow up does SNAC do anything other than get it through the stomach