vialroom

#oral-glp1 2025-09-13

Saturday11 messages4 participantstimes are UTC
Highlights from this day
  • escalation_anxiety — my oral results were inconsistent week to week and i eventually decided it was me, not the tablet 18:45
  • homa_ir_hugo — coffee is not plain water. i tried it for a month and my results got worse, your mileage will differ 19:42
  • fibre_first — update on the earlier thing changed my mind on the plain water rule after reading how SNAC works, its not a formality, from memory 19:51
  • fibre_first — does taking it with any food at all just waste the dose 20:07
EA

my oral results were inconsistent week to week and i eventually decided it was me, not the tablet

Cited study
Oral Semaglutide 50 mg in Adults with Overweight or Obesity (OASIS 1)
The Lancet · 2023
The high-dose oral. Absorption rules matter enormously here.
HI

SNAC raises the local pH and protects it long enough to cross, thats its whole job

[edited]
HI

coffee is not plain water. i tried it for a month and my results got worse, your mileage will differ

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slightly off topic but is the inconsistency people report about the drug or about how they take it

the inconsistency is mostly technique and admitting that took me about a year

the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted

FF

update on the earlier thing changed my mind on the plain water rule after reading how SNAC works, its not a formality, from memory

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FF

does taking it with any food at all just waste the dose

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FN

switched from injectable to oral, lost some of the effect, switched back after 25 months