PIONEER not OASIS
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#oral-glp1 2026-01-07
Wednesday31 messages7 participantstimes are UTC
Highlights from this day
- thirty_min_wait — the fasting rule cost me my breakfast routine and thats the real reason people quit the oral the oral disappointed me on the mornings i couldnt manage 30 minutes… 20:59
- thirty_min_wait — plain water only, about half a glass, then nothing for 30 minutes. i follow it exactly 21:07
- melb_meniscus — lost 37kg over 26 months on oral, slower than my injectable stretch, i stuck with it anyway 22:13
unrelated but coffee is not plain water. i tried it for a month and my results got worse, ymmv
did anyone go back to injecting after trying oral
the inconsistency is mostly technique and admitting that took me about a year
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changed my mind on the plain water rule after reading how SNAC works, its not a formality
the oral mg number is bigger because almost none of it gets in, thats the entire reason
anyone dosing oral because of a needle problem rather than preference
the fasting rule cost me my breakfast routine and thats the real reason people quit the oral
the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them
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why does the same tablet do different things week to week
plain water only, about half a glass, then nothing for 30 minutes. i follow it exactly
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took 9 weeks before i saw anything on oral, roughly twice what the injection took me
is the plain water rule actually load bearing or is it a formality
OASIS ran under the same sort of fasting conditions, thats not the variable between the two
right so took mine with breakfast once by accident and that week was a write off
does coffee count as plain water, asking for obvious reasons
coffee doesnt count
i was wrong about the water amount, i was using a sip and it needs a lot more than that, take that with a pinch of salt
the fasting window is the difference between a dose and a very expensive tablet
switched from injectable to oral, lost some of the effect, switched back after 19 months
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my oral results were inconsistent week to week and i eventually decided it was me, not the tablet
i keep the tablet by the kettle so i take it before i think about food
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i said 6 months ago that my oral results were random, they got consistent once i fixed the water
does taking it with any food at all just waste the dose
nobody should copy my morning routine, but the timer is the bit i would keep
PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
splitting a dose made the absorption problem worse rather than better in my own log
lost 37kg over 26 months on oral, slower than my injectable stretch, i stuck with it anyway
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anyone switched from injectable to oral and kept the same effect
did anyone find the oral easier on the gut than the injection
nobody should copy my morning routine, but the timer is the bit i would keep
SNAC does the work
[edited]big mg small dose