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#oral-glp1 2026-05-07

Thursday16 messages5 participantstimes are UTC
Highlights from this day
  • logrotate — unrelated but one percent is the number people quote and the spread around it is the actual story 18:22
  • logrotate — took 15 weeks before i saw anything on oral, roughly twice what the injection took me 18:45
  • logrotate — the fasting window is the difference between a dose and a very expensive tablet, happy to be corrected 18:46
  • per_mg_pete — absorption is the variable, not the molecule. same tablet, different morning, different result 18:53
  • lean_mass_lex — sorry to jump in PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses, i could be wrong 19:34
LO

unrelated but one percent is the number people quote and the spread around it is the actual story

Cited study
Oral Semaglutide 50 mg in Adults with Overweight or Obesity (OASIS 1)
The Lancet · 2023
The high-dose oral. Absorption rules matter enormously here.
LO

took 15 weeks before i saw anything on oral, roughly twice what the injection took me

Cited study
Oral Semaglutide 50 mg in Adults with Overweight or Obesity (OASIS 1)
The Lancet · 2023
The high-dose oral. Absorption rules matter enormously here.

the fasting window is the difference between a dose and a very expensive tablet, happy to be corrected

ruined my breakfast

👍1🧪15

i was wrong about the water amount, i was using a sip and it needs a lot more than that

PM

absorption is the variable, not the molecule. same tablet, different morning, different result

💀9🎉5

how much water exactly, is it a small sip or half a glass

PIONEER not OASIS

LM

sorry to jump in PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses, i could be wrong

changed my mind on the plain water rule after reading how SNAC works, its not a formality