SNAC does the work
#oral-glp1 2025-10-25
Saturday39 messages8 participantstimes are UTC
Highlights from this day
- oli_orals — did anyone find the oral easier on the gut than the injection 14:57
- oli_orals — tea also does not count, in case anyone was hoping, n of 1 obviously 15:03
- oasis_ola — i use it because needles are a genuine problem for me, not because i think its better, we shall see 15:19
- oasis_ola — plain water only, about half a glass, then nothing for 30 minutes. i follow it exactly 15:42
- oasis_ola — took 17 weeks before i saw anything on oral, roughly twice what the injection took me, for what its worth 17:48
ruined my breakfast
fasted every morning
did anyone find the oral easier on the gut than the injection
*Janoshik not the other one
set a timer
tea also does not count, in case anyone was hoping, n of 1 obviously
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i use it because needles are a genuine problem for me, not because i think its better, we shall see
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took mine with breakfast once by accident and that week was a write off
update on the earlier thing i said 8 months ago that my oral results were random, they got consistent once i fixed the water
plain water only, about half a glass, then nothing for 30 minutes. i follow it exactly
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the non peptide agents dose daily without the water ritual, thats the practical difference
lost 45kg over 12 months on oral, slower than my injectable stretch, i stuck with it anyway
not a peptide
why does the same tablet do different things week to week
orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ
switched from injectable to oral, lost some of the effect, switched back after 20 months
about one percent
coffee is not plain water. i tried it for a month and my results got worse, n of 1 obviously
anyone switched from injectable to oral and kept the same effect
my oral results were inconsistent week to week and i eventually decided it was me, not the tablet
PIONEER or OASIS, which one was the higher dose oral
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SNAC raises the local pH and protects it long enough to cross, thats its whole job
nobody should copy my morning routine, but the timer is the bit i would keep
PIONEER not OASIS
[edited]took 17 weeks before i saw anything on oral, roughly twice what the injection took me, for what its worth
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is orforglipron a peptide at all
the oral mg number is bigger because almost none of it gets in, thats the entire reason
the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted
*PeptideMeter not the other one
thirty minutes, no cheating
back after 4 months, has anything changed on the oral side
plain water only
Purity check: no report on file for lot KP-0925. Nothing logged either way.
one percent is the number people quote and the spread around it is the actual story
coffee doesnt count
[edited]does taking it with any food at all just waste the dose
mine was patchy too
changed my mind on the plain water rule after reading how SNAC works, its not a formality
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