#oral-glp1 2025-09-10

is the absorption variability why the oral doses look so high

tea also does not count, in case anyone was hoping
PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses

took 8 weeks before i saw anything on oral, roughly twice what the injection took me

Reminder set. I will post here in 6 days.

is the non peptide thing why orforglipron doesnt need the fasting rules

genuine question absorption is the variable, not the molecule. same tablet, different morning, different result

does coffee count as plain water, asking for obvious reasons

splitting a dose made the absorption problem worse rather than better in my own log

one percent is the number people quote and the spread around it is the actual story

SNAC does the work

went back to injecting because the morning routine was too fragile around shift work

orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ

plain water only

the fasting window is the difference between a dose and a very expensive tablet

went back to injecting

back after 2 months, has anything changed on the oral side

mine was patchy too

Recon calculator: 40mg in 3ml = 2.5mg/ml.

update on the earlier thing switched from injectable to oral, lost some of the effect, switched back after 6 months

the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted, not advice obviously