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#oral-glp1 2025-07-27

Sunday32 messages6 participantstimes are UTC
Highlights from this day
  • noct.titrate — oral was easier on my gut than injecting at what felt like a similar effect, which surprised me, ymmv 10:19
  • truncation_tru — anyone switched from injectable to oral and kept the same effect 10:44
  • two_three_lifts — update on the earlier thing took 24 weeks before i saw anything on oral, roughly twice what the injection took me nobody should copy my morning routine, but the timer… 12:07
  • two_three_lifts — i use it because needles are a genuine problem for me, not because i think its better the 30 minutes starts when you swallow it, and i set a timer because i cannot be… 12:54
  • two_three_lifts — SNAC raises the local pH and protects it long enough to cross, thats its whole job 13:27
OO

coffee is not plain water. i tried it for a month and my results got worse, for what its worth

OO

the inconsistency is mostly technique and admitting that took me about a year

is the absorption variability why the oral doses look so high

how long before the oral did anything measurable for you

[edited]

my oral results were inconsistent week to week and i eventually decided it was me, not the tablet

NT

oral was easier on my gut than injecting at what felt like a similar effect, which surprised me, ymmv

OO

is the plain water rule actually load bearing or is it a formality

i do 6am with water and eat at 7, thats been my routine for 26 months

ok so absorption is the variable, not the molecule. same tablet, different morning, different result

the non peptide orals are the interesting part of this channel now, not oral semaglutide

did anyone find the oral easier on the gut than the injection

TT

the fasting rule cost me my breakfast routine and thats the real reason people quit the oral

TO

the fasting window is the difference between a dose and a very expensive tablet, not advice obviously

coffee doesnt count

TT

went back to injecting because the morning routine was too fragile around shift work

TT

update on the earlier thing took 24 weeks before i saw anything on oral, roughly twice what the injection took me
nobody should copy my morning routine, but the timer is the bit i would keep

TT

the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted

i use it because needles are a genuine problem for me, not because i think its better
the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted

🙏3
TT

i was wrong about the water amount, i was using a sip and it needs a lot more than that

is orforglipron a peptide at all

TO

switched from injectable to oral, lost some of the effect, switched back after 8 months

fasted every morning

👍17🧊9

is the non peptide thing why orforglipron doesnt need the fasting rules

*VendorInvestigate not the other one