#oral-glp1 2025-10-14

big mg small dose

PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses

is the absorption variability why the oral doses look so high

went back to injecting

plain water only

i keep the tablet by the kettle so i take it before i think about food

not a peptide

i was wrong about the water amount, i was using a sip and it needs a lot more than that, we shall see

mine was patchy too

the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted

oral was easier on my gut than injecting at what felt like a similar effect, which surprised me

the inconsistency is mostly technique and admitting that took me about a year

did anyone go back to injecting after trying oral

set a timer

did anyone find the oral easier on the gut than the injection

orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ

my oral results were inconsistent week to week and i eventually decided it was me, not the tablet

is there any point splitting an oral dose

thirty minutes, no cheating

genuine question does the 30 minutes start from swallowing or from the water

the non peptide agents dose daily without the water ritual, thats the practical difference

the oral mg number is bigger because almost none of it gets in, thats the entire reason

fasted every morning

coffee doesnt count

did OASIS use the same fasting conditions as the earlier work

roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose

i do 6am with water and eat at 7, thats been my routine for 17 months

SNAC does the work

whats the bioavailability actually like, i keep seeing about one percent