how strict is the 30 minute wait before food for people here
#oral-glp1 2025-11-04
Tuesday28 messages7 participantstimes are UTC
Highlights from this day
- karl_fischer — how long before the oral did anything measurable for you 15:05
- vialkeeper — PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses 16:15
- two_eight_c — genuine question tea also does not count, in case anyone was hoping 16:48
- bench_notes — anyone dosing oral because of a needle problem rather than preference the fasting rule cost me my breakfast routine and thats the real reason people quit the oral 16:49
is the absorption variability why the oral doses look so high
sorry to jump in went back to injecting because the morning routine was too fragile around shift work
PIONEER not OASIS
technique probably
coming back to this my oral results were inconsistent week to week and i eventually decided it was me, not the tablet
ok so coffee is not plain water. i tried it for a month and my results got worse
plain water only
is the non peptide thing why orforglipron doesnt need the fasting rules
genuine question the oral mg number is bigger because almost none of it gets in, thats the entire reason, ill dig out the number
fasted every morning
ok so SNAC raises the local pH and protects it long enough to cross, thats its whole job
set a timer
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how long before the oral did anything measurable for you
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one percent is the number people quote and the spread around it is the actual story
the 30 minutes starts when you swallow it, and i set a timer because i cannot be trusted
about one percent
ruined my breakfast
orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ, i could be wrong
switched from injectable to oral, lost some of the effect, switched back after 16 months
big mg small dose
PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
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took 26 weeks before i saw anything on oral, roughly twice what the injection took me
does coffee count as plain water, asking for obvious reasons
i take mine at 6am, is 30 minutes really enough
is the plain water rule actually load bearing or is it a formality
genuine question tea also does not count, in case anyone was hoping
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anyone dosing oral because of a needle problem rather than preference
the fasting rule cost me my breakfast routine and thats the real reason people quit the oral