#oral-glp1 2026-03-07

one percent is the number people quote and the spread around it is the actual story, from memory

the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them

does SNAC do anything other than get it through the stomach

anyone tracking whether their oral results line up week to week

my oral results were inconsistent week to week and i eventually decided it was me, not the tablet, i could be wrong

i use it because needles are a genuine problem for me, not because i think its better

about one percent

update on the earlier thing the fasting window is the difference between a dose and a very expensive tablet

took 26 weeks before i saw anything on oral, roughly twice what the injection took me

why does the same tablet do different things week to week

did anyone get consistent results on the oral or is it always patchy

plain water only, about half a glass, then nothing for 30 minutes. i follow it exactly

the oral mg number is bigger because almost none of it gets in, thats the entire reason

for the archive why is the oral dose in mg so much bigger than the injectable one

went back to injecting

plain water only

quick one roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose

does taking it with any food at all just waste the dose

i do 6am with water and eat at 7, thats been my routine for 7 months, happy to be corrected
OASIS ran under the same sort of fasting conditions, thats not the variable between the two

coffee is not plain water. i tried it for a month and my results got worse

absorption is the variable, not the molecule. same tablet, different morning, different result

the non peptide orals are the interesting part of this channel now, not oral semaglutide, for what its worth

is the inconsistency people report about the drug or about how they take it

technique probably

the inconsistency is mostly technique and admitting that took me about a year, ymmv
my oral results were inconsistent week to week and i eventually decided it was me, not the tablet

switched from injectable to oral, lost some of the effect, switched back after 17 months, for what its worth

big mg small dose

thirty minutes, no cheating

whats the bioavailability actually like, i keep seeing about one percent

took mine with breakfast once by accident and that week was a write off, i could be wrong

Inter-lab diff for lot E-2205: 98.6% vs 98.1%. Within expected range.

went back to injecting because the morning routine was too fragile around shift work

did OASIS use the same fasting conditions as the earlier work

about one percent

changed my mind on the plain water rule after reading how SNAC works, its not a formality