PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
#oral-glp1 2026-03-01
Sunday38 messages6 participantstimes are UTC
Highlights from this day
- constipation_con — SNAC raises the local pH and protects it long enough to cross, thats its whole job 19:23
- bengaluru_bac — back after 4 months, has anything changed on the oral side 19:24
- constipation_con — the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them 19:34
- constipation_con — update on the earlier thing changed my mind on the plain water rule after reading how SNAC works, its not a formality 19:35
set a timer
is the plain water rule actually load bearing or is it a formality
fasted every morning
tea also does not count, in case anyone was hoping
anyone tracking whether their oral results line up week to week
🧪2🙏1📈7
did anyone get consistent results on the oral or is it always patchy
plain water only, about half a glass, then nothing for 30 minutes. i follow it exactly
coffee doesnt count
i do 6am with water and eat at 7, thats been my routine for 24 months
technique probably
i take mine at 6am, is 30 minutes really enough
one percent is the number people quote and the spread around it is the actual story
PIONEER not OASIS
[edited]roughly one percent gets absorbed, which is why the tablet strength looks nothing like an injectable dose
took 6 weeks before i saw anything on oral, roughly twice what the injection took me
thirty minutes, no cheating
is the non peptide thing why orforglipron doesnt need the fasting rules
update on the earlier thing took mine with breakfast once by accident and that week was a write off
switched from injectable to oral, lost some of the effect, switched back after 21 months
i said 11 months ago that my oral results were random, they got consistent once i fixed the water
🙏2👍1❤️2
orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ
is the inconsistency people report about the drug or about how they take it
changed my mind on the plain water rule after reading how SNAC works, its not a formality
the non peptide agents dose daily without the water ritual, thats the practical difference
i keep the tablet by the kettle so i take it before i think about food
did anyone go back to injecting after trying oral
my oral results were inconsistent week to week and i eventually decided it was me, not the tablet
the oral mg number is bigger because almost none of it gets in, thats the entire reason
follow up nobody should copy my morning routine, but the timer is the bit i would keep
i was wrong about the water amount, i was using a sip and it needs a lot more than that, ask me again in a month
update on the earlier thing why does the same tablet do different things week to week
OASIS ran under the same sort of fasting conditions, thats not the variable between the two
went back to injecting
does coffee count as plain water, asking for obvious reasons
SNAC raises the local pH and protects it long enough to cross, thats its whole job
🧪9💀8
back after 4 months, has anything changed on the oral side
🔥15🧊2🙏8
the oral disappointed me on the mornings i couldnt manage 30 minutes fasted, which was most of them
🧪11⚠️3
update on the earlier thing changed my mind on the plain water rule after reading how SNAC works, its not a formality
🧪1👍12
anyone dosing oral because of a needle problem rather than preference