no data on that
#maintenance 2026-04-26
Sunday41 messages10 participantstimes are UTC
Highlights from this day
- tarpit_tam — completely off the map. that doesnt make it dangerous, it makes it unstudied. those are different words and people swap them 16:30
- tarpit_tam — the reason it isnt absurd is the half-life. about a week means a fortnightly schedule still leaves you with meaningful drug on board at day 14 16:40
- bengaluru_bac — respect for saying it straight 17:47
- coa_or_cope — yeah. #mental-health has a whole conversation about the silence going away 18:09
- bengaluru_bac — fair. im staying weekly and lowering the dose instead 18:20
does anyone budget for maintenance being cheaper or is it the same £240 a month
lower frequency maintenance is genuinely unstudied. anybody telling you it is proven is making that up
two or three kilos up and down is normal fluctuation. ten is a different conversation
follow up i weigh weekly at maintenance rather than daily and my range is about two kilos either side
for the archive i think about it the way i think about my blood pressure tablet, and that framing helped me more than anything else, i think
if you find maintenance harder than the losing part you are in the majority in this room
Purity check: no report on file for lot KP-0925. Nothing logged either way.
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lift twice a week
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come down slower than that
[edited]went back up, no regrets
there is no official maintenance dose. it is a thing we do because the alternative on the table was stopping
Reminder set. I will post here in 8 days.
question for the channel. anyone doing every other week rather than a lower weekly dose
loads of people are. its all over the place
before the anecdotes arrive, let me say the boring thing once. there is no trial data on this. none
not a small trial, not a subgroup, not a secondary endpoint. every registration programme is fixed weekly dosing
so everyone doing it is off the map
completely off the map. that doesnt make it dangerous, it makes it unstudied. those are different words and people swap them
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the reason it isnt absurd is the half-life. about a week means a fortnightly schedule still leaves you with meaningful drug on board at day 14
the honest reason people do it is cost, isnt it
for most of us yes. halving the frequency halves the bill and maintenance is the part you pay for forever
is nobody studying maintenance dosing at all
maintenance as a research question is badly underfunded relative to how many people are in it. thats my opinion not a fact
flagged as opinion, thats all we ask
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the thing that made maintenance work for me wasnt the dose, it was the lifting
i went from nothing to twice a week during the loss phase and i am convinced it is why my floor is where it is
convinced on what evidence though
none that would survive this channel. my own body and a mirror
respect for saying it straight
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the general principle has decades behind it though. resistance training defends lean mass during energy deficit, that part isnt controversial
what is unknown is how much of the lean mass loss in the GLP-1 trials would have been prevented by structured training, because the trials didnt do that
how much lean mass loss are we talking
in the imaging substudies its a meaningful share of total mass lost, broadly in line with what youd expect from any comparable weight loss. see #food-and-training, theres a longer version there
the appetite return is the part i wasnt ready for
not hunger. hunger i can handle. the running commentary coming back is the horrible bit
yeah. #mental-health has a whole conversation about the silence going away
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back to the no-data thing — if someone asked you point blank whether fortnightly is safe, what do you say
i say i dont know, nobody knows, and anyone who sounds certain is selling something or hasnt read anything
and that is why he is the liaison
fair. im staying weekly and lowering the dose instead
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