Topic
Tirzepatide
Page 9 of 15 — Dual GIP/GLP-1 agonism, the SURMOUNT and SURPASS trials, the 2.5 to 15mg ladder, and the argument about whether anyone needs the…
Messages — page 9 of 15
deadspaceappetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point, someone check my working#retatrutide · 2025-11-08ten_of_tendid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2025-11-08split_dose_samappetite came back over about three weeks after i reduced, not all at once, which is what i had braced for, thats just me#maintenance · 2025-11-09plus_sixteeni weigh weekly at maintenance rather than daily and my range is about two kilos either side#maintenance · 2025-11-10fridge_six_twoGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2025-11-11alcohol_hitsis the GI worse than tirzepatide or about the same#retatrutide · 2025-11-12alcohol_hitsfollow up appetite suppression at 5 was stronger than my tirzepatide experience at a comparable point the phase 2 weight…#retatrutide · 2025-11-12karl_fischerGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2025-11-12HPLC_Hanktirzepatide is about 4813.5 Da, so 2+ is near 2407.8 and 3+ near 1605.5#hplc-massspec · 2025-11-12electrolyte_elilow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom, i could be wrong#retatrutide · 2025-11-13travel_coolertirzepatide is about 4813.5 Da, so 2+ is near 2407.8 and 3+ near 1605.5#hplc-massspec · 2025-11-13gip_glp_gilthe sweet spot thing is survivorship, the people it worked for stayed and said so#tirzepatide · 2025-11-14area_percenttirzepatide is about 4813.5 Da, so 2+ is near 2407.8 and 3+ near 1605.5#hplc-massspec · 2025-11-15two_three_liftsappetite suppression at 15 was stronger than my tirzepatide experience at a comparable point#retatrutide · 2025-11-16salt_bridgeSURMOUNT-1 — tirzepatide once weekly in obesity without diabetes#food-and-training · 2025-11-16tokyo_taperis it bad form to say i havent had a single side effect#wins · 2025-11-17red_flag_rubylow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom phase 2 doses are published…#retatrutide · 2025-11-18thirty_min_waitdo you get bloods every 2 months or only when something changes#bloodwork · 2025-11-18food_noise_offi nearly quit too#wins · 2025-11-19amylin_amyis the GI worse than tirzepatide or about the same#retatrutide · 2025-11-20amylin_amyappetite suppression at 7.5 was stronger than my tirzepatide experience at a comparable point#retatrutide · 2025-11-20two_lifts_a_week12 did nothing extra over 10 for me and that still holds a year later#tirzepatide · 2025-11-21lyophile_livis the GI worse than tirzepatide or about the same#retatrutide · 2025-11-22fake_trackinglow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom, ill dig out the number#retatrutide · 2025-11-22triumph_watchdid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2025-11-22ferritin_fay40 units of a 2.5 solution is a lot of volume and i check that one twice every single time#tirzepatide · 2025-11-24first_month_fiis the GI worse than tirzepatide or about the same#retatrutide · 2025-11-24taper_or_notstepping back down on purpose is a completely reasonable move and this channel should say so more often, n of 1 obviously#dosing-titration · 2025-11-26two_three_liftswhats your rule for when a side effect means hold rather than push#dosing-titration · 2025-11-26assay_not_purityis the GI worse than tirzepatide or about the same#retatrutide · 2025-11-27factory_direct_fiappetite suppression at 2 was stronger than my tirzepatide experience at a comparable point#retatrutide · 2025-11-27vale_vialsi drifted from sunday to wednesday over a year and only noticed when i checked the log#dosing-titration · 2025-11-27cricket_or_footyis the GI worse than tirzepatide or about the same#retatrutide · 2025-11-28madrid_mglow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2025-11-28first_and_last_fourappetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point#retatrutide · 2025-11-28tarpit_tamtirzepatide is about 4813.5 Da, so 2+ is near 2407.8 and 3+ near 1605.5#hplc-massspec · 2025-11-30sage_sourceswent 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step#semaglutide · 2025-12-01tokyo_taperis the GI worse than tirzepatide or about the same#retatrutide · 2025-12-01week_three_wallis the GI worse than tirzepatide or about the same#retatrutide · 2025-12-02revoked_roquick one low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2025-12-04pinch_not_stretchGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2025-12-04a1c_lagslightly off topic but the FLOW result is why my nephrologist changed her position on this entirely#bloodwork · 2025-12-04related_subsmine did the same#bloodwork · 2025-12-04sulphur_burpthe argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess#dosing-titration · 2025-12-05night_pinlow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom stopped for 17 months and…#retatrutide · 2025-12-06lean_mass_lexmonths not weeks#wins · 2025-12-06mhra_unlicensedim on 5mg tirz fortnightly having lost on 10 weekly. thats a quarter of the weekly exposure and it holds#dosing-titration · 2025-12-07mhra_unlicensedmy actual maintenance maths since people always ask#dosing-titration · 2025-12-07HPLC_Hankthe sweet spot argument is really about effect per side effect, not a magic number#tirzepatide · 2025-12-08sulphur_burpdid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2025-12-08private_script_priGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2025-12-08surpass_twolow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2025-12-09surpass_twoGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2025-12-09surpass_twodid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2025-12-09two_lifts_a_weeklow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2025-12-12two_lifts_a_weekGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2025-12-12point_two_fivelow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2025-12-13relabel_watchdid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2025-12-13sgp_subqis the GI worse than tirzepatide or about the same#retatrutide · 2025-12-13alcohol_hitsthe trials titrated every four weeks to a target, most people here stop at whatever works#tirzepatide · 2025-12-14