Topic
Oral GLP-1s
Page 2 of 13 — Oral semaglutide with SNAC, roughly one percent bioavailability, the fasting and plain-water rules, and the non-peptide orals…
Messages — page 2 of 13
endotoxin_edthe non peptide orals are the interesting part of this channel now, not oral semaglutide, take that with a pinch of salt#oral-glp1 · 2025-02-22endotoxin_edis orforglipron a peptide at all#oral-glp1 · 2025-02-22triumph_watchok so SNAC raises the local pH and protects it long enough to cross, thats its whole job, from memory#oral-glp1 · 2025-02-22oasis_olaSNAC does the work#oral-glp1 · 2025-03-02power_through_noPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2025-03-02oasis_olaoral was easier on my gut than injecting at what felt like a similar effect, which surprised me, for what its worth#oral-glp1 · 2025-03-02pharmac_penSNAC raises the local pH and protects it long enough to cross, thats its whole job, from memory#oral-glp1 · 2025-03-02oasis_oladoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-03-02oasis_olais the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-03-02meniscus_melorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2025-03-06meniscus_melSNAC does the work#oral-glp1 · 2025-03-06two_four_ceilingis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-03-06area_percentdoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-03-06oasis_oladoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-03-08related_subsSNAC does the work#oral-glp1 · 2025-03-08maintenance_moPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2025-03-08cold_start_cythe non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2025-03-10vialkeeperchanged my mind on the plain water rule after reading how SNAC works, its not a formality, i have it written down somewhere#oral-glp1 · 2025-03-15slow.taperdoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-03-18taper_tessthe non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2025-03-18taper_tessis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-03-18slow.taperorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2025-03-18month_six_meSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2025-03-22ghk_giais orforglipron a peptide at all#oral-glp1 · 2025-03-26clothes_size_cassPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2025-03-26rezept_rolfslightly off topic but SNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2025-03-26rezept_rolfthe non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2025-03-26cagri_curiousslightly off topic but PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2025-03-29appetite_backthe non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2025-03-31eighteen_monthsPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses the fasting rule cost me my…#oral-glp1 · 2025-03-31pbs_pipSNAC does the work#oral-glp1 · 2025-04-01see_a_clinicianis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-04-01amylin_amyPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2025-04-02net_peptideSNAC does the work#oral-glp1 · 2025-04-02ms_ms_mirathe non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2025-04-03transit_degradedoes SNAC do anything other than get it through the stomach#oral-glp1 · 2025-04-03first_and_last_fourSNAC does the work#oral-glp1 · 2025-04-07cold_chain_cmdrdid OASIS use the same fasting conditions as the earlier work#oral-glp1 · 2025-04-07cold_chain_cmdrSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2025-04-07thirty_min_waitis orforglipron a peptide at all#oral-glp1 · 2025-04-10mag_citratechanged my mind on the plain water rule after reading how SNAC works, its not a formality, happy to be corrected#oral-glp1 · 2025-04-13lipase_loreorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2025-04-14blind_submitok so does SNAC do anything other than get it through the stomach#oral-glp1 · 2025-04-14ring_size_downis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-04-19ring_size_downSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2025-04-19reship_ritais orforglipron a peptide at all#oral-glp1 · 2025-04-19dublin_dosethe non peptide agents dose daily without the water ritual, thats the practical difference the fasting window is the…#oral-glp1 · 2025-04-19never_for_saleSNAC does the work#oral-glp1 · 2025-04-19two_ml_twois the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-04-26retention_timeis orforglipron a peptide at all the fasting rule cost me my breakfast routine and thats the real reason people quit the oral#oral-glp1 · 2025-04-26retention_timechanged my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2025-04-26luerlokSNAC does the work#oral-glp1 · 2025-04-26retention_timeorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ, thats one data point#oral-glp1 · 2025-04-26residual_solventright so does SNAC do anything other than get it through the stomach#oral-glp1 · 2025-04-26thirty_min_waitPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2025-04-26oasis_olais the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2025-04-28orfor_watchcoming back to this PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2025-04-28lipase_loreis orforglipron a peptide at all#oral-glp1 · 2025-04-28egfr_ednobody should copy my morning routine, but the timer is the bit i would keep#oral-glp1 · 2025-04-28oasis_olaright so SNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2025-04-28