thirty minutes, no cheating
#oral-glp1 2025-04-28
Monday39 messages8 participantstimes are UTC
Highlights from this day
- orfor_watch — for the archive i do 6am with water and eat at 7, thats been my routine for 11 months 22:30
- HPLC_Hank — does the 30 minutes start from swallowing or from the water i said 18 months ago that my oral results were random, they got consistent once i fixed the water 22:47
- egfr_ed — nobody should copy my morning routine, but the timer is the bit i would keep 22:49
- madrid_mg — the non peptide agents dose daily without the water ritual, thats the practical difference 23:04
- HPLC_Hank — the fasting rule cost me my breakfast routine and thats the real reason people quit the oral 23:11
for the archive i do 6am with water and eat at 7, thats been my routine for 11 months
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is the non peptide thing why orforglipron doesnt need the fasting rules
coming back to this PIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses
why is the oral dose in mg so much bigger than the injectable one
whats the bioavailability actually like, i keep seeing about one percent
is orforglipron a peptide at all
mine was patchy too
coffee is not plain water. i tried it for a month and my results got worse, take that with a pinch of salt
splitting a dose made the absorption problem worse rather than better in my own log, thats just me
does the 30 minutes start from swallowing or from the water
i said 18 months ago that my oral results were random, they got consistent once i fixed the water
nobody should copy my morning routine, but the timer is the bit i would keep
went back to injecting
went back to injecting because the morning routine was too fragile around shift work
did anyone find the oral easier on the gut than the injection
ruined my breakfast
why does the same tablet do different things week to week
plain water only
i take mine at 6am, is 30 minutes really enough
[edited]tea also does not count, in case anyone was hoping
the non peptide agents dose daily without the water ritual, thats the practical difference
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how strict is the 30 minute wait before food for people here
plain water only, about half a glass, then nothing for 30 minutes. i follow it exactly
the fasting rule cost me my breakfast routine and thats the real reason people quit the oral
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switched from injectable to oral, lost some of the effect, switched back after 6 months
i use it because needles are a genuine problem for me, not because i think its better
took mine with breakfast once by accident and that week was a write off
one percent is the number people quote and the spread around it is the actual story
absorption is the variable, not the molecule. same tablet, different morning, different result, i have it written down somewhere
the oral mg number is bigger because almost none of it gets in, thats the entire reason
the inconsistency is mostly technique and admitting that took me about a year
anyone dosing oral because of a needle problem rather than preference
right so SNAC raises the local pH and protects it long enough to cross, thats its whole job
anyone switched from injectable to oral and kept the same effect
coffee doesnt count
[edited]i said 7 months ago that my oral results were random, they got consistent once i fixed the water
is the absorption variability why the oral doses look so high
switched from injectable to oral, lost some of the effect, switched back after 2 months
follow up the fasting window is the difference between a dose and a very expensive tablet, i have it written down somewhere
*Medutest not the other one