#oral-glp1 2025-04-14

Monday16 messages4 participantstimes are UTC

Highlights from this day

lipase_lore — orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ 17:28
lipase_lore — oral was easier on my gut than injecting at what felt like a similar effect, which surprised me, happy to be corrected 17:37
lipase_lore — took 27 weeks before i saw anything on oral, roughly twice what the injection took me 17:40
lipase_lore — absorption is the variable, not the molecule. same tablet, different morning, different result 17:43
blind_submit — i said 6 months ago that my oral results were random, they got consistent once i fixed the water, still working it out 18:42

splitting a dose made the absorption problem worse rather than better in my own log

orforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ

oral was easier on my gut than injecting at what felt like a similar effect, which surprised me, happy to be corrected

took 27 weeks before i saw anything on oral, roughly twice what the injection took me

fasted every morning

absorption is the variable, not the molecule. same tablet, different morning, different result

big mg small dose

medutest-report-b-0329.pdf

3 pages · 814 KB · not retained in the public archive

while im here PIONEER or OASIS, which one was the higher dose oral

does the 30 minutes start from swallowing or from the water

i take mine at 6am, is 30 minutes really enough

ok so does SNAC do anything other than get it through the stomach

i said 6 months ago that my oral results were random, they got consistent once i fixed the water, still working it out

i use it because needles are a genuine problem for me, not because i think its better

technique probably

👍15👀4

PIONEER not OASIS

is the absorption variability why the oral doses look so high