Topic
Oral GLP-1s
Page 9 of 13 — Oral semaglutide with SNAC, roughly one percent bioavailability, the fasting and plain-water rules, and the non-peptide orals…
Messages — page 9 of 13
mhra_unlicensedPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2026-03-01chlorhexis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2026-03-01constipation_conorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2026-03-01constipation_confollow up nobody should copy my morning routine, but the timer is the bit i would keep#oral-glp1 · 2026-03-01constipation_conSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2026-03-01constipation_conupdate on the earlier thing changed my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2026-03-01vial_ledgeris the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2026-03-04split_dose_samdoes SNAC do anything other than get it through the stomach#oral-glp1 · 2026-03-04vial_ledgerSNAC raises the local pH and protects it long enough to cross, thats its whole job, i have it written down somewhere#oral-glp1 · 2026-03-04vial_ledgeris orforglipron a peptide at all#oral-glp1 · 2026-03-04vial_ledgeris orforglipron a peptide at all#oral-glp1 · 2026-03-04seoul_swirlcoming back to this SNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2026-03-05knees_firstthe non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2026-03-05spreadsheet_stuis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2026-03-06clove_chartschanged my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2026-03-06triumph_watchdoes SNAC do anything other than get it through the stomach#oral-glp1 · 2026-03-06tail_factordoes SNAC do anything other than get it through the stomach#oral-glp1 · 2026-03-07fridge_thermoSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2026-03-07quiet_head_qiorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2026-03-07fridge_thermoSNAC does the work#oral-glp1 · 2026-03-07mag_citratethe non peptide orals are the interesting part of this channel now, not oral semaglutide, for what its worth#oral-glp1 · 2026-03-07bea_reconstituteschanged my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2026-03-07quiet_head_qiunrelated but the non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2026-03-08quiet_head_qiPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2026-03-08night_pinSNAC does the work#oral-glp1 · 2026-03-08quiet_head_qiSNAC raises the local pH and protects it long enough to cross, thats its whole job, someone check my working#oral-glp1 · 2026-03-08alt_ast_aliis orforglipron a peptide at all#oral-glp1 · 2026-03-09seven_five_sweetgenuine question the non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2026-03-09vienna_vialanyone dosing oral because of a needle problem rather than preference#oral-glp1 · 2026-03-10early_satietychanged my mind on the plain water rule after reading how SNAC works, its not a formality lost 11kg over 24 months on oral,…#oral-glp1 · 2026-03-13lena_lotsSNAC raises the local pH and protects it long enough to cross, thats its whole job, ill dig out the number#oral-glp1 · 2026-03-17acetate_ashSNAC does the work#oral-glp1 · 2026-03-17orfor_watchSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2026-03-18wrong_networkSNAC does the work#oral-glp1 · 2026-03-18tga_noticethe non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2026-03-21cold_chain_cmdrswitched from injectable to oral, lost some of the effect, switched back after 21 months#oral-glp1 · 2026-03-21provincial_patis the non peptide thing why orforglipron doesnt need the fasting rules#oral-glp1 · 2026-03-21cold_chain_cmdrorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2026-03-21panel_before_afterthe non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2026-03-22amsterdam_aliquotok so changed my mind on the plain water rule after reading how SNAC works, its not a formality, for what its worth#oral-glp1 · 2026-03-22vacuum_vicPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2026-03-22vacuum_vicSNAC does the work#oral-glp1 · 2026-03-22nordic_price_nilsslightly off topic but changed my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2026-03-23nordic_price_nilsPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2026-03-23chlorhexSNAC raises the local pH and protects it long enough to cross, thats its whole job#oral-glp1 · 2026-03-27bench_notesthe non peptide orals are the interesting part of this channel now, not oral semaglutide#oral-glp1 · 2026-03-27quiet.hoursSNAC does the work#oral-glp1 · 2026-03-28fasting_insulinchanged my mind on the plain water rule after reading how SNAC works, its not a formality, thats one data point#oral-glp1 · 2026-03-28verify_or_dontSNAC raises the local pH and protects it long enough to cross, thats its whole job, your mileage will differ#oral-glp1 · 2026-03-29vial_ledgerplain water only#oral-glp1 · 2026-03-29snac_and_waterorforglipron is a small molecule rather than a peptide, which is why the fasting conditions differ#oral-glp1 · 2026-03-29snac_and_waterPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2026-03-29snac_and_waterthe non peptide orals are the interesting part of this channel now, not oral semaglutide my oral results were inconsistent…#oral-glp1 · 2026-03-29bpc_scepticchanged my mind on the plain water rule after reading how SNAC works, its not a formality#oral-glp1 · 2026-03-29bpc_scepticfollow up is orforglipron a peptide at all oral was easier on my gut than injecting at what felt like a similar effect, which…#oral-glp1 · 2026-03-29iris_importsSNAC does the work#oral-glp1 · 2026-03-29acetate_ashdoes SNAC do anything other than get it through the stomach#oral-glp1 · 2026-04-01acetate_ashPIONEER was the original oral semaglutide programme and OASIS looked at the higher oral doses#oral-glp1 · 2026-04-01snac_and_waterSNAC does the work#oral-glp1 · 2026-04-02rotate_the_siteis orforglipron a peptide at all#oral-glp1 · 2026-04-02