coming back to this how much water exactly, is it a small sip or half a glass
#oral-glp1 2025-05-10
Saturday39 messages10 participantstimes are UTC
Highlights from this day
anyone tracking whether their oral results line up week to week
did anyone go back to injecting after trying oral
coffee doesnt count
mine was patchy too
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is the absorption variability why the oral doses look so high
SNAC does the work
so is the 50mg oral actually equivalent to the 2.4 injection or is that a convenient story
68 weeks, mean weight reduction around 15%, which is broadly in the same territory as the injection trials
so it is equivalent
similar result in a similar population. thats not the same as equivalent in you
the distinction this whole channel is built on
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the variability is the real difference. injected absorption is fairly predictable, oral absorption is not
two people on identical 50mg tablets can end up with quite different exposure
how different
the pharmacokinetic variability for oral sema is substantially wider than for the injection. thats well described
which means the dose you swallow is a much weaker predictor of the dose you receive
that would explain my last four months
same tablet, same routine, weekly weigh in
wk 1-6 steady loss, ~0.6kg/wk
wk 7 nothing
wk 8 nothing
wk 9 -1.4kg in one week
wk 10-13 nothing again
wk 14 -1.8kg
i changed nothing. food logged, same scale, same day.
this is not what my four months on the pen looked like.
that looks broken
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it looks like absorption noise to me. thats the pattern people describe on oral and almost never on injected
or its water weight and a coincidence. two data points of movement is not much
fair, but the flat weeks were properly flat
i lean towards absorption too, but @karl_fischer is right that this log cannot distinguish the two
is there any way to check
not practically. you would need drug levels and nobody is running those on themselves
the honest comparison, without pretending we know more than we do
| Injected 2.4 weekly | Oral 50 mg daily | |
|---|---|---|
| Trial weight result | about -15% (STEP 1) | about -15% (OASIS 1) |
| Dosing | once weekly | every day, fasted |
| Bioavailability | high, predictable | around 1%, variable |
| Main failure mode | you forget the day | you break the fasting rule |
| Needles | yes | no |
that last row is the only reason im in this channel to be honest
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its a completely valid reason and nobody should be sniffy about it
archive lookup: oral appears in 96 lines in #oral-glp1. 11 mention breaking the fasting window, 9 mention going back to injections.
nine out of eleven is a hell of a conversion rate
small numbers, but the direction has been the same since 2024
the variability point — is that why people keep saying oral feels inconsistent rather than weak
exactly that. weak would at least be reliable. inconsistent is harder to plan around
that is a very good way of putting it
about one percent
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my oral results were inconsistent week to week and i eventually decided it was me, not the tablet, from memory
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the inconsistency is mostly technique and admitting that took me about a year