Topic
Tirzepatide
Page 15 of 15 — Dual GIP/GLP-1 agonism, the SURMOUNT and SURPASS trials, the 2.5 to 15mg ladder, and the argument about whether anyone needs the…
Messages — page 15 of 15
rotate_the_sitedid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2026-05-29peak_splitlow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2026-05-30lead_time_larstirzepatide is about 4813.5 Da, so 2+ is near 2407.8 and 3+ near 1605.5#hplc-massspec · 2026-05-30triumph_watchlow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2026-05-31rotate_the_sitetirzepatide is about 4813.5 Da, so 2+ is near 2407.8 and 3+ near 1605.5, we shall see semaglutide is about 4113.6 Da. [M+2H]2+…#hplc-massspec · 2026-05-31customs_owlfollow up is the GI worse than tirzepatide or about the same the half life supports weekly dosing and thats what ive done from…#retatrutide · 2026-06-01tb500_tobiasthe maintenance conversation barely existed in here two years ago and now it is half the channel#maintenance · 2026-06-01slow.taperfor the archive is the GI worse than tirzepatide or about the same#retatrutide · 2026-06-02void_volumeright so tirzepatide is about 4813.5 Da, so 2+ is near 2407.8 and 3+ near 1605.5#hplc-massspec · 2026-06-03ghk_gialow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom, i think#retatrutide · 2026-06-04ollie_ordersdid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2026-06-04void_volumeGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2026-06-05adelaide_assayappetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point#retatrutide · 2026-06-05hair_month_fourlow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2026-06-05clove_chartsdid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2026-06-06evidence_or_notwhile im here GI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2026-06-06identity_shiftSURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted#tirzepatide · 2026-06-07eat_more_pleaseGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2026-06-07swab_dry_firstappetite suppression at 2.5 was stronger than my tirzepatide experience at a comparable point#retatrutide · 2026-06-07evidence_or_notlow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2026-06-07hard_stop_hallow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2026-06-10split_the_costok so did the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2026-06-10batch_banditlow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2026-06-11void_volumetirzepatide is about 4813.5 Da, so 2+ is near 2407.8 and 3+ near 1605.5#hplc-massspec · 2026-06-12appetite_backlow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2026-06-13net_peptidestart low anyway#tirzepatide · 2026-06-14halifax_hplcunrelated but GI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2026-06-14retention_timefor the archive tirzepatide is about 4813.5 Da, so 2+ is near 2407.8 and 3+ near 1605.5#hplc-massspec · 2026-06-14adelaide_assaylow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2026-06-15adelaide_assayappetite suppression at 2 was stronger than my tirzepatide experience at a comparable point, we shall see#retatrutide · 2026-06-15reta_low_doselow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2026-06-16blind_submitappetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point, someone check my working#retatrutide · 2026-06-16nhs_pathway_nellat 7.5 my appetite went completely and i dropped back a step, eating nothing isnt a win#tirzepatide · 2026-06-17ferritin_fayGI was about the same as tirzepatide for me, the difference was how fast it arrived, i have it written down somewhere#retatrutide · 2026-06-17two_three_liftsis the GI worse than tirzepatide or about the same#retatrutide · 2026-06-17is_this_foreverappetite suppression at 0.5 was stronger than my tirzepatide experience at a comparable point#retatrutide · 2026-06-17deadspaceappetite suppression at 0.5 was stronger than my tirzepatide experience at a comparable point#retatrutide · 2026-06-17two_three_liftslow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2026-06-18coa_or_copetirzepatide is about 4813.5 Da, so 2+ is near 2407.8 and 3+ near 1605.5#hplc-massspec · 2026-06-18chaser_chrisis the GI worse than tirzepatide or about the same#retatrutide · 2026-06-21acetate_ashappetite suppression at 12 was stronger than my tirzepatide experience at a comparable point#retatrutide · 2026-06-21still_here_2024how do you celebrate this without it being about food#wins · 2026-06-21ida_injectsGI was about the same as tirzepatide for me, the difference was how fast it arrived nobody should read my log as a plan, im…#retatrutide · 2026-06-22blank_runis the GI worse than tirzepatide or about the same#retatrutide · 2026-06-23blank_runlow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2026-06-23cat_on_the_traytirzepatide is about 4813.5 Da, so 2+ is near 2407.8 and 3+ near 1605.5#hplc-massspec · 2026-06-23mag_citratelow and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom#retatrutide · 2026-06-24elm_escalatesGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2026-06-25cold_start_cyappetite suppression at 0.5 was stronger than my tirzepatide experience at a comparable point no idea whether the heart rate…#retatrutide · 2026-06-25septum_salif you only get one thing, get a fasting insulin. it is the one that becomes impossible later#bloodwork · 2026-06-26ghent_gradientcoming back after 11 months of maintenance, is anyone interested in the numbers#maintenance · 2026-06-26retention_timedid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2026-06-27food_noise_offGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2026-06-27LC_MS_Lenatirzepatide is about 4813.5 Da, so 2+ is near 2407.8 and 3+ near 1605.5, still working it out#hplc-massspec · 2026-06-28factory_direct_fiSELECT is the stopping one. weight came back on for most people once the drug stopped. that is the finding, not an opinion#maintenance · 2026-06-28low_and_slowis the GI worse than tirzepatide or about the same#retatrutide · 2026-06-29no_appetite_niadid the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2026-06-29low_and_slowGI was about the same as tirzepatide for me, the difference was how fast it arrived#retatrutide · 2026-06-29tarpit_tamdoes moving my dose day by two days matter with a seven day half life#semaglutide · 2026-06-30still_here_2024did the phase 2 result actually come in higher than the tirzepatide numbers#retatrutide · 2026-06-30