Recon calculator: 20mg in 2ml = 10mg/ml.
#semaglutide 2026-06-30
Tuesday73 messages12 participantstimes are UTC
Highlights from this day
- freya_fridge — restarted after 10 months off at a low dose and the nausea arrived exactly like the first time 21:06
- relabel_watch — right so moving my dose day by a day or two never did anything noticeable for me the plateau hit me at 5 weeks and moved again about a month later without a dose change 21:21
- freya_fridge — compounded and brand felt the same to me at 10, which is one person and nothing more 22:46
what did SELECT actually measure, i see it quoted for everything
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anyone compared their 2.5 vial dosing against the pen increments
[edited]anyone gone from 7.5 straight to 2.5 or is that too big a jump
does the licensed ceiling for weight differ from the diabetes one
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plateaus move
my dose day drifted from friday to sunday, does that reset anything
went too fast once
does anyone actually run a five week step instead of four
STEP is several trials, so saying STEP said x is usually wrong without a number after it, someone check my working
i dont think the plateau is a dose problem most of the time, but i cant prove that
quick one going slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
vial units and pen clicks are different systems, mixing the two is how people end up wrong
steady state takes weeks
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
give it four weeks
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went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
[edited]i held at 1 for 2 months and it was the best decision i made
im 6 months in at 2 and the appetite effect faded, is that a thing
how long till steady state, ive read the half life is about a week
did anyone titrate slower than four weeks a step and how did that go
does moving my dose day by two days matter with a seven day half life
same dose day
STEP 1 ran to 68 weeks. thats the one everyone half remembers
STEP 4 had the withdrawal arm, thats the one people quote when they talk about stopping
restarted after 10 months off at a low dose and the nausea arrived exactly like the first time
😂4🧪8⚠️15
my 2 vial in 3ml gives 10mg/ml so 15 lands on 20 units, thats why i picked that volume, from memory
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem, your mileage will differ
did anyone hold at 15 longer than four weeks before going up
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seven days ish
held there too
*VendorInvestigate not the other one
right so moving my dose day by a day or two never did anything noticeable for me
the plateau hit me at 5 weeks and moved again about a month later without a dose change
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not the same trial
the long half life flattens the trough more than people expect, i never felt a day seven dip
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2.4 is the ceiling
14 months at 2.4 and the honest summary is diminishing returns after the first half
i stayed on 1.7 for 6 months and never went to 2.4, appetite was already where i needed it
dose day is sunday for me only because thats when i remember, not because sunday matters
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how did people handle the jump from 1 to 1.7
quick one licensed ceiling for weight is 2.4 weekly, anything above that is not a licensed dose
SELECT was cardiovascular outcomes in people with overweight and existing disease, not a weight trial
vials not pens here
coming back to this the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
the plateau hit me at 26 weeks and moved again about a month later without a dose change
whats the actual licensed ceiling, i keep seeing different numbers
is there a reason to hold at 1.7 rather than going to 2.4
five week steps worked better for me than four, purely on how the second week felt
slower worked better
is the plateau at 22 weeks normal or am i doing something wrong
SELECT wasnt weight
changed my mind on the four week rule, i think it depends entirely on how the current dose feels
how long did the first 20kg take for people at the low doses
thats STEP 1
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
the appetite effect faded for me around 9 months and going up fixed it for a while
did the STEP 4 withdrawal arm show what i think it showed
i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication, thats just me
compounded and brand felt the same to me at 10, which is one person and nothing more
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was SELECT the one that ran to 68 weeks or am i mixing them up
back after 17 months off, do i restart at 0.25 or somewhere higher
quick one held at 2.5 and lost 77lb over 23 months, slower than the trials and fine by me
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
how many weeks before you noticed anything at 15
$38 a month for compounded against what brand costs locally is why most people here use vials
SELECT wasnt weight
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SELECT wasnt weight
FLOW was the kidney outcomes trial and it gets quoted in here for things it didnt measure
is the plateau usually appetite coming back or just the scale stopping
went to 2.4 and the extra suppression wasnt worth the GI for me, so i came back down
did anybody find a difference between Homopeptide and pharmacy at the same 15
2.4 is the ceiling
*Medutest not the other one
lost about 39kg on the low doses before i even got to 1, which surprised me, thats one data point