vialroom
Fortnightly digest · 2025-04-21 → 2025-05-04

one percent bioavailability and the bet that started in off-topic

The oral channel had its best fortnight, largely because somebody finally read the absorption data instead of complaining that oral does not work. The fasting rules are strict, almost nobody follows them exactly, and that accounts for a lot of the disappointment. It also produced a standing bet in the off-topic channel that would run for the next fourteen months.

4.5Kmessages
173day logs
3channels noted
5notes

What happened

  • OASIS 1 in Lancet 2023 was the anchor for the fortnight, read alongside the practical business of plain water and thirty minutes of nothing else.
  • Coffee counts as something by mouth, which several members had decided did not apply to them personally.
  • The non-peptide orals were distinguished from oral semaglutide on the specific ground that they do not carry the same food restriction.
  • The bet was framed as whether a non-peptide oral is generally available before the end of 2026, with no money involved and the loser writing a digest.
  • A member pointed out that the ledger for the bet is the only pinned document here that nobody has ever tried to amend.

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