Fortnightly digest · 2025-04-21 → 2025-05-04
one percent bioavailability and the bet that started in off-topic
The oral channel had its best fortnight, largely because somebody finally read the absorption data instead of complaining that oral does not work. The fasting rules are strict, almost nobody follows them exactly, and that accounts for a lot of the disappointment. It also produced a standing bet in the off-topic channel that would run for the next fourteen months.
4.5Kmessages
173day logs
3channels noted
5notes
What happened
- OASIS 1 in Lancet 2023 was the anchor for the fortnight, read alongside the practical business of plain water and thirty minutes of nothing else.
- Coffee counts as something by mouth, which several members had decided did not apply to them personally.
- The non-peptide orals were distinguished from oral semaglutide on the specific ground that they do not carry the same food restriction.
- The bet was framed as whether a non-peptide oral is generally available before the end of 2026, with no money involved and the loser writing a digest.
- A member pointed out that the ledger for the bet is the only pinned document here that nobody has ever tried to amend.
Channels this fortnight
#oral-glp1Oral semaglutide, SNAC absorption, orforglipron and the non-peptide orals.3 logs · 93 msgs#off-topicEverything else. Fridge thermometers, cats, the 2026 bet, dinner.7 logs · 207 msgs#semaglutideSemaglutide. STEP and SELECT data, 0.25 to 2.4mg, and what happens above it.13 logs · 469 msgs
Most-reacted messages in this fortnight
Pulled from the logs, not hand-picked. Each links to the exact message.
lean_mass_lexbac water45 reactions · #reconstitution · 2025-04-23a1c_lagthats the win44 reactions · #wins · 2025-04-23cold_chain_cmdrcooking a curry i will eat a third of and enjoy every bite of. that is the deal now42 reactions · #off-topic · 2025-04-22ruo_onlya fresh pin for the injection hurts less. whether thats worth the extra dead space is your call41 reactions · #injection-technique · 2025-04-26coa_or_copesummarised by quarter so it is readable41 reactions · #test-results · 2025-04-26pharmac_pentwo sessions a week40 reactions · #food-and-training · 2025-05-04seizure_letterthe combination is the thing with trial data behind it, monotherapy in here is mostly us guessing39 reactions · #cagrilintide · 2025-04-25reship_ritadid anyone get through the nhs route and how long was it end to end39 reactions · #uk-ireland · 2025-04-26
Busiest logs in this fortnight
#semaglutide · 2025-04-26went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step61 msgs#semaglutide · 2025-05-01back after 5 months off, do i restart at 0.25 or somewhere higher55 msgs#tirzepatide · 2025-05-02titrate slow53 msgs#side-effects · 2025-04-28if you are under 1000 calories by accident that is a problem, not discipline, thats one data point51 msgs#side-effects · 2025-04-22sulphur burps. is there anything at all that helps50 msgs#vendor-talk · 2025-04-24prices move without announcement more often than people expect. screenshot your invoice, take that with a…49 msgs#tirzepatide · 2025-04-28right so SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted48 msgs#off-topic · 2025-05-03what do you tell visitors the little thermometer in the fridge is for48 msgs#semaglutide · 2025-04-22vials not pens here47 msgs#semaglutide · 2025-04-25not the same trial47 msgs#dosing-titration · 2025-04-27thats normal47 msgs#semaglutide · 2025-04-30was SURMOUNT-1 the one that ran to 68 weeks or am i mixing them up47 msgs