not the same trial
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#semaglutide 2025-04-25
Friday47 messages9 participantstimes are UTC
Highlights from this day
- half_life_hal — does moving my dose day by two days matter with a seven day half life 21:48
- see_a_clinician — how did people handle the jump from 1 to 1.7 21:58
- see_a_clinician — STEP is several trials, so saying STEP said x is usually wrong without a number after it 22:00
- month_six_me — changed my mind on the four week rule, i think it depends entirely on how the current dose feels 22:33
- blank_run — my plateau was the scale stopping while appetite stayed suppressed, which is a different problem 22:51
is 2.4 the top or do people go past it
held at 0.5 and lost 63lb over 16 months, slower than the trials and fine by me, anyway
janoshik-e-2205.pdf
2 pages · 921 KB · not retained in the public archive
for the archive my dose day drifted from friday to sunday, does that reset anything
whats the actual licensed ceiling, i keep seeing different numbers
does moving my dose day by two days matter with a seven day half life
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg18 months at 2.4 and the honest summary is diminishing returns after the first half
*Medutest not the other one
does anyone actually run a five week step instead of four
genuine question went 1 to 1.7 too fast and spent two weeks regretting it, dropped back and repeated the step
how did people handle the jump from 1 to 1.7
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STEP is several trials, so saying STEP said x is usually wrong without a number after it
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went too fast once
what did SELECT actually measure, i see it quoted for everything
while im here did anybody find a difference between KP and pharmacy at the same 2.4
genuine question does the licensed ceiling for weight differ from the diabetes one
[edited]anyone gone from 0.25 straight to 10 or is that too big a jump
vials not pens here
steady state is the bit people skip, judging a new dose after eight days tells you almost nothing
im at 1.7 and stuck, did anyone break a plateau without going up
is there a reason to hold at 1.7 rather than going to 2.4
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moving my dose day by a day or two never did anything noticeable for me
did anyone titrate slower than four weeks a step and how did that go
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SELECT wasnt weight
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back after 7 months off, do i restart at 0.25 or somewhere higher
€185 a month for compounded against what brand costs locally is why most people here use vials, for what its worth
seven days ish
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changed my mind on the four week rule, i think it depends entirely on how the current dose feels
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did anyone hold at 2.4 longer than four weeks before going up
moving my dose day by a day or two never did anything noticeable for me
2.4 is the ceiling
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mggoing slow cost me nothing except time and saved me two bad weeks, thats my whole contribution
STEP 1 ran to 68 weeks. thats the one everyone half remembers, for what its worth
[edited]give it four weeks
the plateau hit me at 19 weeks and moved again about a month later without a dose change
my plateau was the scale stopping while appetite stayed suppressed, which is a different problem
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how long did the first 28kg take for people at the low doses
same dose day
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i was wrong about the ceiling for a year, i thought 3 existed. it doesnt for the weight indication
plateaus move
the trials titrated on a fixed schedule, most people here dont, worth remembering when comparing
how long till steady state, ive read the half life is about a week
i stayed on 1.7 for 19 months and never went to 2.4, appetite was already where i needed it
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slower worked better
restarted after 22 months off at a low dose and the nausea arrived exactly like the first time
update on the earlier thing anyone compared their 4 vial dosing against the pen increments
half_life_halthe trials titrated on a fixed schedule, most people here dont, worth remembering when…
the long half life flattens the trough more than people expect, i never felt a day seven dip